764736
Poly(ethylene glycol) methyl ether-block-poly(D,L lactide)-block-decane
PEG average Mn 2,000, PDLLA average Mn 2,000
Synonym(s):
PEG-PDLLA-decane, PEG-b-PLA-b-decane, PEG-PLA
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About This Item
UNSPSC Code:
12162002
NACRES:
NA.23
Recommended Products
form
pellets
Quality Level
mol wt
PDLLA average Mn 2,000
PEG average Mn 2,000
average Mn 4,000 (total)
degradation timeframe
2-5 weeks
transition temp
Tm 29-33 °C
PDI
<1.1 (typical PEG)
<1.2
<1.3 (overall)
storage temp.
2-8°C
General description
Block copolymer micelles are widely used in drug delivery applications. PEG-PDLLA is a biodegradable polymeric micelle which is used as a carrier for hydrophobic drugs like Paclitaxel. The hydrophilic PEG and hydrophobic PDLLA form the micelle core wherein the hydrophobic drug is loaded. The incorporation of the 10-alkyl end cap (decane) increases the hydrophobicity of the micelle core and increases its solubilizing capability for hydrophobic drugs.†
Application
Used as a carrier for the controlled and targeted release of anticancer hydrophobic drugs.
Features and Benefits
- Good biocompatibility, low immunogenicity and good degradability.
- Properties can be easily modulated by changing the block copolymer segment sizes to suit a particular application.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
>230.0 °F
Flash Point(C)
> 110 °C
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Hongtao Chen et al.
Proceedings of the National Academy of Sciences of the United States of America, 105(18), 6596-6601 (2008-05-01)
It is generally assumed that polymeric micelles, upon administration into the blood stream, carry drug molecules until they are taken up into cells followed by intracellular release. The current work revisits this conventional wisdom. The study using dual-labeled micelles containing
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