725668
Poly(N-isopropylacrylamide), N-hydroxysuccinimide (NHS) ester terminated
average Mn 2,000
Synonym(s):
NIPAM polymer, PNIPAM-NHS, Polyacrylamide, functionalized polyNIPAM, functionalized polyacrylamide, polyNIPAM
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About This Item
Linear Formula:
(C6H11NO)n SCH2CH2COO(C4H4NO2)
UNSPSC Code:
12162002
NACRES:
NA.23
Recommended Products
form
powder
mol wt
average Mn 2,000
mp
>300 °C
Application
Novel polymer for development of thermosensitive coated micro/nano materialincluding thermoresponsive polymeric drug delivery systems. The NHS ester functional group can be used to conjugate a variety of biomolecules such as enzymes† to the polymer chain.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Certificates of Analysis (COA)
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Rzaev, Z.M.O.; Dincer, S.; Piskin, E.
Progress in Polymer Science, 32, 534-534 (2007)
K Fujimoto et al.
Biomacromolecules, 1(4), 515-518 (2001-11-17)
We report a novel drug delivery system for apoptosis induction by a "smart" polymer vehicle possessing thermosensitivity and bioaffinity. The polymer chain was prepared by copolymerization of N-isopropylacrylamide and N-methacryloyloxysuccinimide. Cell-adhesive RGDS peptide was conjugated with the copolymer as a
Chung, J. E.; Yokoyama, M.; Suzuki, K.; Aoyagi, T.; Sakurai, Y.; Okano, T.
Colloids and Surfaces, B: Biointerfaces, 9, 37-37 (1997)
Hua Wei et al.
Biomaterials, 28(1), 99-107 (2006-09-09)
A four-arm star block copolymer, comprised of a hydrophobic PMMA arm and an average of three hydrophilic poly(N-isopropylacrylamide) (PNIPAAm) arms were designed and synthesized from the molecular level. The amphiphilic star block copolymer is capable of self-assembling into micelles in
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