391549

Dimethyl aminomalonate hydrochloride

97%

• Synonym(s): Aminomalonic acid dimethyl ester hydrochloride
• Linear Formula: NH₂CH(COOCH₃)₂ · HCl
• CAS Number: 16115-80-3
• Molecular Weight: 183.59
• Beilstein: 3696467
• EC Number: 240-284-5
• MDL number: MFCD00038880
• UNSPSC Code: 12352100
• PubChem Substance ID: 24864387
• NACRES: NA.22

Properties

• Assay: 97%
• form: crystals
• mp: 160 °C (dec.) (lit.)
• solubility: water: soluble 25 mg/mL, clear, colorless to faintly yellow
• functional group: amine; ester
• SMILES string: Cl[H].COC(=O)C(N)C(=O)OC
• InChI: 1S/C5H9NO4.ClH/c1-9-4(7)3(6)5(8)10-2;/h3H,6H2,1-2H3;1H
• InChI key: QWNDKNJSEWOEDM-UHFFFAOYSA-N

Description

General description

Dimethyl aminomalonate hydrochloride is a hydrochloride salt of a dialkyl aminomalonate.

Application

Dimethyl aminomalonate hydrochloride (aminomalonic acid dimethyl ester hydrochloride) may be used in synthesis of methyl 3-phenyl-5-hydantoincarboxylate and Boc-Leu-Ama(OMe)₂(Boc= tert-butyloxycarbonyl, Leu= leucine, Ama= aminomalonic acid). It may be used as starting reagent in the synthesis of the following:

• (R,S)-2-phenethylcysteine hydrochloride
• dimethyl 2,2,2-polynitroalkylnitroaminonitromalonate
• spirotryprostatin B

Safety Information

• Pictograms: GHS07
• Signal Word: Warning
• Hazard Statements: H315,H319,H335
• Precautionary Statements: P261 - P264 - P271 - P280 - P302 + P352 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Target Organs: Respiratory system
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves