Anti-KCNT1 antibody detects endogenous levels of total KCNT1 protein.
The KCNT1 (potassium sodium-activated channel subfamily T member 1) gene is mapped to human chromosome 9q34.3. It is widely expressed in the brain, heart and dorsal root ganglia and well distributed in the nervous system.
Immunogen
The antiserum was produced against synthesized peptide derived from human KCNT1.
Immunogen Range: 1019-1068
Biochem/physiol Actions
Mutations in KCNT1 (potassium sodium-activated channel subfamily T member 1) is observed in different epileptic disorders including epileptic encephalopathy, nocturnal frontal lobe epilepsy and malignant migrating partial seizures in infancy. KCNT1 is associated with neural oscillation and general learning disability. It also controls pain sensation.
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Physical form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Disclaimer
Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.
Stimulation of Slack K(+) Channels Alters Mass at the Plasma Membrane by Triggering Dissociation of a Phosphatase-Regulatory Complex.
Fleming MR
Cell Reports, 16(9), 2281-2288 (2016)
Characterization of two de novoKCNT1 mutations in children with malignant migrating partial seizures in infancy.
Rizzo F
Molecular and Cellular Neurosciences, 72, 54-63 (2016)
Epilepsy-Related Slack Channel Mutants Lead to Channel Over-Activity by Two Different Mechanisms.
Tang QY
Cell Reports, 9314(1), 129-139 (2016)
Mutations in KCNT1 cause a spectrum of focal epilepsies.
M?ller RS
Epilepsia, 56(9) (2015)
Missense mutations in the sodium-gated potassium channel gene KCNT1 cause severe autosomal dominant nocturnal frontal lobe epilepsy.
Heron SE
Nature Genetics, 44(11), 1188-1190 (2012)
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