SAB1300727

Anti-Phospho-TEK-Y992 antibody produced in rabbit

affinity isolated antibody, buffered aqueous solution

• Synonym(s): Anti-TEKT1, Anti-Tektin-1
• UNSPSC Code: 12352203
• NACRES: NA.41

Properties

• biological source: rabbit
• Quality Level: 100
• conjugate: unconjugated
• antibody form: affinity isolated antibody
• antibody product type: primary antibodies
• clone: polyclonal
• form: buffered aqueous solution
• species reactivity: human
• technique(s): dot blot: suitable; indirect ELISA: 1:1000
• NCBI accession no.: NP_444515
• UniProt accession no.: Q969V4
• shipped in: dry ice
• storage temp.: −20°C
• target post-translational modification: phosphorylation (pTyr992)
• Gene Information: human ... TEK(83659)

Description

General description

The TEK receptor tyrosine kinase is expressed almost exclusively in endothelial cells in mice, rats, and humans. This receptor possesses a unique extracellular domain containing 2 immunoglobulin-like loops separated by 3 epidermal growth factor-like repeats that are connected to 3 fibronectin type III-like repeats. The ligand for the receptor is angiopoietin-1. Defects in TEK are associated with inherited venous malformations; the TEK signaling pathway appears to be critical for endothelial cell-smooth muscle cell communication in venous morphogenesis. TEK is closely related to the TIE receptor tyrosine kinase.

Immunogen

TEK (NP_444515, 977-1009)
This antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding Y992 of human TEK.

Physical form

Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide.

Safety Information

• Storage Class Code: 10 - Combustible liquids
• WGK: nwg
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable