RAB0016
Human Angiopoietin-2 ELISA Kit
for serum, plasma, cell culture supernatant and urine
Synonym(s):
Angiopoietin-2
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All Photos(2)
About This Item
UNSPSC Code:
41116158
NACRES:
NA.32
Recommended Products
species reactivity
human
packaging
kit of 96 wells (12 strips x 8 wells)
technique(s)
ELISA: suitable
capture ELISA: suitable
input
sample type urine
sample type serum
sample type cell culture supernatant(s)
sample type plasma
assay range
inter-assay cv: <12%
intra-assay cv: <10%
sensitivity: 10 pg/mL
standard curve range: 4.12-3000 pg/mL
detection method
colorimetric
shipped in
wet ice
storage temp.
−20°C
Gene Information
human ... ANGPT2(285)
General description
The Human Angiopoietin-2 ELISA (Enzyme-Linked Immunosorbent Assay) kit is an in vitro enzyme-linked immunosorbent assay for the quantitative measurement of human Angiopoietin-2 in serum, plasma, cell culture supernatants and urine.
Immunogen
Recombinant Human Angiopoietin-2
Application
For research use only. Not for use in diagnostic procedures.
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Please refer to the attached General ELISA KIT Procedure (sandwich, competitive & Indirect ELISA)
Biochem/physiol Actions
Angiopoietin-2 (ANGPT2) belongs to the family of angiogenic factors. ANGPT2 is a competitive antagonist of ANGPT1 and reduces vascular stabilization. ANGPT2 is a potent marker for liver cancer. ANGPT2 binds with tyrosine kinase with immunoglobulin-like and endothelial growth factor (EGF)-like domains 2 (Tie-2) and causes neoangiogenesis in liver cirrhosis. Upregulation of ANGPT2 might have an adverse effect on kidney physiology and function. Overexpression of ANGPT2 leads to endothelial damage and dysfunction resulting in diabetic nephropathy in diabetic patients. ANGPT2 is a potent marker for detecting lung cancer progression. Upregulation of ANGPT2 promotes signal transduction for tumor progression in epithelial ovarian cancer.
Other Notes
A sample Certificate of Analysis is available for this product.
Please type the word sample in the text box provided for lot number.
Please type the word sample in the text box provided for lot number.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Met. Corr. 1
Storage Class Code
8A - Combustible corrosive hazardous materials
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Angiopoietin-2, Renal Deterioration, Major Adverse Cardiovascular Events and All-Cause Mortality in Patients with Diabetic Nephropathy
Tsai YC, et al.
Kidney & Blood Pressure Research, 43, 545-554 (2018)
Angiopoietin-2 serum levels are elevated in patients with liver cirrhosis and hepatocellular carcinoma
Scholz A, et al.
The American Journal of Gastroenterology, 102(11), 2471-2481 (2007)
The role of serum angiopoietin-2 levels in progression and prognosis of lung cancer: A meta-analysis
Xu Y, et al.
Medicine, 96(37), e8063-e8063 (2017)
Angiopoietin-2 (Ang-2) is a useful serum tumor marker for liver cancer in the Chinese population
Chen Y, et al.
Clinica Chimica Acta; International Journal of Clinical Chemistry, 478, 18-27 (2018)
Crosstalk between TEMs and endothelial cells modulates angiogenesis and metastasis via IGF1-IGF1R signalling in epithelial ovarian cancer
Wang X, et al.
British Journal of Cancer, 117(9), 1371-1382 (2017)
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