D7815
R(−)-Denopamine
≥98% (HPLC), powder
Synonym(s):
(−)-α-(3,4-Dimethoxyphenethylaminomethyl)-4-hydroxybenzylalcohol
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About This Item
Empirical Formula (Hill Notation):
C18H23NO4
CAS Number:
Molecular Weight:
317.38
MDL number:
UNSPSC Code:
12352116
PubChem Substance ID:
NACRES:
NA.77
Recommended Products
Quality Level
Assay
≥98% (HPLC)
form
powder
color
white
solubility
DMSO: 10 mg/mL, clear
H2O: insoluble
storage temp.
2-8°C
SMILES string
COc1ccc(CCNC[C@H](O)c2ccc(O)cc2)cc1OC
InChI
1S/C18H23NO4/c1-22-17-8-3-13(11-18(17)23-2)9-10-19-12-16(21)14-4-6-15(20)7-5-14/h3-8,11,16,19-21H,9-10,12H2,1-2H3/t16-/m0/s1
InChI key
VHSBBVZJABQOSG-INIZCTEOSA-N
Gene Information
human ... ADRB1(153)
Application
R(-)-Denopamine has been used as an β-adrenergic agonist to study its effects on contractility in isolated lymphatic vessels (LVs).
Biochem/physiol Actions
Denopamine is a cardiotonic drug.
β1-adrenoceptor agonist.
Features and Benefits
This compound is featured on the β-Adrenoceptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Caution
Light sensitive.
Signal Word
Warning
Hazard Statements
Precautionary Statements
Hazard Classifications
Repr. 2
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Personal Protective Equipment
dust mask type N95 (US), Eyeshields, Gloves
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Weak arrhythmogenic property of the new cardiotonic agent denopamine in dogs: comparison with catecholamines
NARITA H, et al.
Japanese Journal of Pharmacology, 41(3), 335-344 (1986)
H Kurosawa et al.
Japanese journal of pharmacology, 72(4), 325-333 (1996-12-01)
Influence of cardiotonic agents on the prognosis of heart failure depends on the individual therapeutic agents, and favorable and unfavorable effects of these agents have been reported in clinical trials. We studied the effect of the cardiotonic agent denopamine on
Barry M Trost et al.
Organic letters, 4(16), 2621-2623 (2002-08-03)
[reaction: see text] Syntheses of variously modified ligands for the dinuclear zinc catalysts for the asymmetric aldol and nitroaldol (Henry) reactions are reported. Catalytic enantioselective nitroaldol reactions promoted by these modified ligands led to efficient syntheses of the beta-receptor agonists
Effectiveness of low dose denopamine, a beta1-adrenoceptor agonist, in a patient with vasospastic angina refractory to intensive medical treatment.
Dainari Nakajima et al.
International journal of cardiology, 108(2), 281-283 (2005-05-26)
Takeshi Ishide
Current medical research and opinion, 18(7), 407-413 (2002-12-19)
Up until now, it has been suggested that nitrate and/or calcium channel blockers were effective against variant angina pectoris. On the other hand, it is known that about 20% of variant angina pectoris was refractory to both nitrate and calcium
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