Skip to Content
Merck
All Photos(5)

Documents

C3019

Sigma-Aldrich

Coenzyme A trilithium salt

≥93%

Synonym(s):

CoA Li3

Sign Into View Organizational & Contract Pricing


About This Item

Empirical Formula (Hill Notation):
C21H33Li3N7O16P3S
CAS Number:
Molecular Weight:
785.33
EC Number:
MDL number:
UNSPSC Code:
41106305
PubChem Substance ID:
NACRES:
NA.51

Assay

≥93%

form

powder

storage temp.

−20°C

SMILES string

[Li+].[Li+].[Li+].CC(C)(COP([O-])(=O)OP([O-])(=O)OC[C@H]1O[C@H]([C@H](O)[C@@H]1OP(O)([O-])=O)n2cnc3c(N)ncnc23)C(O)C(=O)NCCC(=O)NCCS

InChI

1S/C21H36N7O16P3S.3Li/c1-21(2,16(31)19(32)24-4-3-12(29)23-5-6-48)8-41-47(38,39)44-46(36,37)40-7-11-15(43-45(33,34)35)14(30)20(42-11)28-10-27-13-17(22)25-9-26-18(13)28;;;/h9-11,14-16,20,30-31,48H,3-8H2,1-2H3,(H,23,29)(H,24,32)(H,36,37)(H,38,39)(H2,22,25,26)(H2,33,34,35);;;/q;3*+1/p-3/t11-,14-,15-,16?,20-;;;/m1.../s1

InChI key

QSCBPHBAFBVXRK-HJKJOZROSA-K

Looking for similar products? Visit Product Comparison Guide

General description

Coenzyme A (CoA) is synthesized from phosphopantothenate by the action of enzyme pantothenate kinase and is the master regulator.

Application

Coenzyme A trilithium salt has been used:
  • in standard curve generation in the kinetic assay of acetyltransferase Gcn5 acylation
  • as a cofactor in JNADH and JNADPH production assay
  • in the labeling of Alexa647 (AF647) probe

Biochem/physiol Actions

Coenzyme A (CoA, CoASH, HSCoA) is a coenzyme that facilitates enzymatic acyl-group transfer reactions and supports the synthesis and oxidation of fatty acids. CoA is involved in the mechanisms of a wide variety of enzymes. Acyl CoA accumulation is implicated in metabolic disorders and may indirectly lead to the pathogenesis associated with carbon-induced mitochondrial stress heart failure, diabetes and obesity.

Other Notes

For more more technical information and a complete list of Coenzyme A deriviatives visit the Acyl Transfer Reagents Resource.

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

Already Own This Product?

Find documentation for the products that you have recently purchased in the Document Library.

Visit the Document Library

Characterization of Fluorescein Arsenical Hairpin (FlAsH) as a Probe for Single-Molecule Fluorescence Spectroscopy
Fernandes DD, et al.
Scientific reports, 7(1), 13063-13063 (2017)
Jessica P Kuppan et al.
eLife, 10 (2021-09-30)
The complement system is a critical host defense against infection, playing a protective role that can also enhance disease if dysregulated. Although many consequences of complement activation during viral infection are well established, mechanisms that determine the extent to which
Structural basis for acyl-group discrimination by human Gcn5L2
Ringel AE and Wolberger C
Acta crystallographica. Section D, Structural biology, 72(7), 841-848 (2016)
Constructing a synthetic pathway for acetyl-coenzyme A from one-carbon through enzyme design
Lu X, et al.
Nature Communications, 10(1), 1378-1378 (2019)
Mitochondrial diagnostics: a multiplexed assay platform for comprehensive assessment of mitochondrial energy fluxes
Fisher-Wellman KH, et al.
Testing, 24(13), 3593-3606 (2018)

Our team of scientists has experience in all areas of research including Life Science, Material Science, Chemical Synthesis, Chromatography, Analytical and many others.

Contact Technical Service