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85976

Sigma-Aldrich

Methoxypolyethylene glycol succinate N-hydroxysuccinimide

5,000, ≥90%

Synonym(s):

Polyethylene glycol, mono-Methyl polyethylene glycol succinate N-succinimidyl ester, O-Methyl-O′-succinylpolyethylene glycol 5,000 N-succinimidyl ester, PEG-succinimidyl succinate

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About This Item

CAS Number:
78274-32-5
MDL number:
MFCD00131598
UNSPSC Code:
12162002
PubChem Substance ID:
57653073
NACRES:
NA.25

Assay

≥90%

form

powder

storage temp.

−20°C

InChI

1S/C11H15NO7/c13-5-6-18-7-8(14)1-4-11(17)19-12-9(15)2-3-10(12)16/h13H,1-7H2

InChI key

OVPTZXRXNNJKSJ-UHFFFAOYSA-N

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Application


  • Matrix metalloproteinases-2/9-sensitive peptide-conjugated polymer micelles for site-specific release of drugs and enhancing tumor accumulation: preparation and in vitro and in vivo evaluation. This study explores the use of Methoxypolyethylene glycol succinate N-hydroxysuccinimide (MPEG-S-NHS) for creating peptide-conjugated polymer micelles that are sensitive to matrix metalloproteinases-2/9. These micelles are designed for site-specific drug release and increased tumor targeting, showcasing a promising application in advanced drug delivery systems (Zhang X, Wang X, Zhong W, Ren X, Sha X, Fang X, 2016) [link].


Linkage

Shearwater Polymers product

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

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M S Hershfield et al.
Proceedings of the National Academy of Sciences of the United States of America, 88(16), 7185-7189 (1991-08-15)
Modification by covalent attachment of polyethylene glycol (PEG) can reduce the immunogenicity and prolong the circulating life of proteins, but the utility of this approach for any protein is restricted by the number and distribution of PEG attachment sites (e.g.
Georgi As Georgiev et al.
Colloids and surfaces. B, Biointerfaces, 59(2), 184-193 (2007-06-26)
Foam thin liquid films (TLF) and monolayers at the air-water interface formed by DMPC mixed with DMPE-bonded poly (ethylene glycol)s (DMPE-PEG(550), DMPE-PEG(2000) and DMPE-PEG(5000)) were obtained. The influence of both (i) PEG chain size (evaluated in terms of Mw) and
H Matsuyama et al.
Biological & pharmaceutical bulletin, 16(2), 107-111 (1993-02-01)
Purified sphingomyelinase of Streptomyces A9107 (NRRL 15100) was modified with ss-PEG, methoxypolyethyleneglycol succinimidyl succinate, without loss of activity toward sphingomyelin in the mixed micelles with detergents such as sodium deoxycholate and Triton X-100 or toward a water-soluble, synthetic substrate, HNP
Charles Mark Ensor et al.
Cancer research, 62(19), 5443-5450 (2002-10-03)
Some murine melanomas and hepatocellular carcinomas (HCCs) have been shown to be auxotrophic for arginine. Arginine deiminase (ADI; EC 3.5.3.6.), an arginine-degrading enzyme isolated from Mycoplasma, can inhibit growth of these tumors. We found that ADI was specific for arginine
H Matsuyama et al.
Chemical & pharmaceutical bulletin, 39(3), 743-746 (1991-03-01)
Phospholipase D from Streptomyces sp. AA586, PLDP, was modified with methoxypolyethylene glycol succinimidylsuccinate (ss-PEG), an active derivative of polyethylene glycol. By titration with trinitrobenzene sulfonate (TNBS), approximately 70% of the free amino groups in the enzyme protein were shown to
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