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BCR266

7H-Dibenzo[c,g]carbazole

BCR®, certified reference material

Synonym(s):

3,4,5,6-Dibenzocarbazole

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About This Item

Empirical Formula (Hill Notation):
C20H13N
CAS Number:
194-59-2
Molecular Weight:
267.32
Beilstein:
213015
MDL number:
MFCD00215941
UNSPSC Code:
41116107
PubChem Substance ID:
329773800
NACRES:
NA.24

grade

certified reference material

Agency

BCR®

manufacturer/tradename

JRC

technique(s)

HPLC: suitable
gas chromatography (GC): suitable

format

neat

storage temp.

2-8°C

SMILES string

[H]n1c2ccc3ccccc3c2c4c1ccc5ccccc45

InChI

1S/C20H13N/c1-3-7-15-13(5-1)9-11-17-19(15)20-16-8-4-2-6-14(16)10-12-18(20)21-17/h1-12,21H

InChI key

STJXCDGCXVZHDU-UHFFFAOYSA-N

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Analysis Note

For more information please see:
BCR266

Legal Information

BCR is a registered trademark of European Commission

Pictograms

Health hazardExclamation mark
GHS08,GHS07

Signal Word

Warning

Hazard Statements

H302,H319,H351

Hazard Classifications

Acute Tox. 4 Oral - Carc. 2 - Eye Irrit. 2

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

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Alena Gábelová et al.
Environmental and molecular mutagenesis, 44(5), 448-458 (2004-11-10)
The cytochrome P4501A subfamily (CYP1A) is involved in the metabolic activation of 7H-dibenzo[c,g]carbazole (DBC) and its tissue- and organ-specific derivatives, N-methyldibenzo[c,g]carbazole (MeDBC)and 5,9-dimethyldibenzo[c,g]carbazole (diMeDBC). In this study, we have evaluated the relationship between the tissue specificity and (32)P-postlabeled adduct patterns
A Gábelová et al.
Mutation research, 469(2), 259-269 (2000-09-14)
7H-dibenzo[c,g]carbazole (DBC) is a potent liver and skin carcinogen, while its synthetic methyl derivative N-methyldibenzo[c,g]carbazole (MeDBC) is tissue specific sarcomagen. It is supposed that sarcomagenic activity of DBC depends on biotransformation at ring-carbon atoms, as with PAH, whereas the heterocyclic
Inmaculada Martín-Burriel et al.
Toxicologic pathology, 32(2), 202-211 (2004-06-18)
The topical administration of 7H-dibenzo[c,g]carbazole (7H-DBC) at very low but repeated doses causes genotoxic effects such as DNA adduct formation and produces hepatocellular apoptosis in mouse liver. The purpose of this work was to investigate the alterations in gene expression
T O'Brien et al.
Toxicology in vitro : an international journal published in association with BIBRA, 16(3), 235-243 (2002-05-22)
7H-Dibenzo[c,g]carbazole (DBC) is a model N-heterocyclic aromatic compound (NHA) which is both a hepatotoxin and hepatocarcinogen in rodents. The focus of this investigation was to determine whether human liver cell lines display differential sensitivities to DBC-induced toxicity. Treatment of cell
K R Mitchell et al.
Molecular carcinogenesis, 32(2), 55-60 (2001-12-18)
Carcinogenic N-heterocyclic aromatic hydrocarbons are formed during the incomplete combustion of fossil fuels as well as cigarette smoke. N-Methyldibenzo[c,g]carbazole (NMeDBC) and 7H-dibenzo[c,g]carbazole (DBC) are members of this group. DBC induces mouse skin and liver tumors, whereas NMeDBC induces only mouse
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