379891

Periodic acid

99.999% trace metals basis

• Empirical Formula (Hill Notation): H₅IO₆
• CAS Number: 10450-60-9
• Molecular Weight: 227.94
• EC Number: 233-937-0
• MDL number: MFCD00011344
• UNSPSC Code: 12352301
• PubChem Substance ID: 24863698
• NACRES: NA.22

Properties

• Quality Level: 200
• Assay: 99.999% trace metals basis
• form: crystals
• reaction suitability: reagent type: oxidant
• mp: 122 °C (lit.)
• solubility: water: soluble
• SMILES string: OI(O)(O)(O)(O)=O
• InChI: 1S/H5IO6/c2-1(3,4,5,6)7/h(H5,2,3,4,5,6,7)
• InChI key: TWLXDPFBEPBAQB-UHFFFAOYSA-N

Description

General description

Periodic acid (H₅IO₆) is an oxoacid of iodine. It is commonly used as an oxidizing agent in organic synthesis for the preparation of useful chemical intermediates. Periodic acid is also used in oxidative cleavage reactions.

Application

Periodic acid can be used as a reagent:

• In the oxidative cleavage of 1,2 diols and epoxides to ketones or aldehydes.
• For the oxidation of alcohols to ketones or aldehydes in the presence of pyridinium chlorochromate as a catalyst.
• For the oxidation of sulfides to sulfones using chromium(VI) oxide catalyst.
• For the oxidation of naphthalenes and anthracene to quinones using chromium(VI) oxide catalyst.
• In the synthesis of polyaniline (Pani) by chemical polymerization.
• N-nitrosation of secondary amines using various heterogeneous catalysts in the presence of Na₂NO₃.
• In combination with sodium bisulfate for the preparation iodohydrin substituents by the addition of I-OH to alkenes.

Safety Information

• Pictograms: GHS03,GHS08,GHS05,GHS09
• Signal Word: Danger
• Hazard Statements: H271,H314,H372,H410
• Precautionary Statements: P210 - P260 - P273 - P280 - P303 + P361 + P353 - P305 + P351 + P338
• Hazard Classifications: Aquatic Acute 1 - Aquatic Chronic 1 - Eye Dam. 1 - Ox. Sol. 1 - Skin Corr. 1B - STOT RE 1 Oral
• Target Organs: Thyroid
• Storage Class Code: 5.1A - Strongly oxidizing hazardous materials
• WGK: WGK 3
• Flash Point(F): Not applicable
• Flash Point(C): Not applicable
• Personal Protective Equipment: dust mask type N95 (US), Eyeshields, Gloves