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30681

Sigma-Aldrich

L-4-Hydroxyproline methyl ester hydrochloride

≥98.0% (GC)

Synonym(s):

(2S,4R)-4-Hydroxypyrrolidine-2-carboxylic acid methyl ester hydrochloride, trans-4-Hydroxyproline methyl ester hydrochloride

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About This Item

Empirical Formula (Hill Notation):
C6H11NO3 · HCl
CAS Number:
40216-83-9
Molecular Weight:
181.62
Beilstein:
4716932
MDL number:
MFCD00080855
UNSPSC Code:
12352209
eCl@ss:
32160406
PubChem Substance ID:
57648453
NACRES:
NA.22

Quality Level

100

Assay

≥98.0% (GC)

form

solid

reaction suitability

reaction type: solution phase peptide synthesis

application(s)

peptide synthesis

SMILES string

Cl.COC(=O)[C@@H]1C[C@@H](O)CN1

InChI

1S/C6H11NO3.ClH/c1-10-6(9)5-2-4(8)3-7-5;/h4-5,7-8H,2-3H2,1H3;1H/t4-,5+;/m1./s1

InChI key

KLGSHNXEUZOKHH-JBUOLDKXSA-N

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point(F)

Not applicable

Flash Point(C)

Not applicable

Personal Protective Equipment

dust mask type N95 (US), Eyeshields, Gloves

Certificates of Analysis (COA)

Search for Certificates of Analysis (COA) by entering the products Lot/Batch Number. Lot and Batch Numbers can be found on a product’s label following the words ‘Lot’ or ‘Batch’.

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Emily M Christensen et al.
The Journal of biological chemistry, 295(52), 18316-18327 (2020-10-29)
Pyrroline-5-carboxylate reductase 1 (PYCR1) catalyzes the biosynthetic half-reaction of the proline cycle by reducing Δ1-pyrroline-5-carboxylate (P5C) to proline through the oxidation of NAD(P)H. Many cancers alter their proline metabolism by up-regulating the proline cycle and proline biosynthesis, and knockdowns of

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