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Merck
  • Design and properties of novel gallium-doped injectable apatitic cements.

Design and properties of novel gallium-doped injectable apatitic cements.

Acta biomaterialia (2015-06-16)
Charlotte Mellier, Franck Fayon, Florian Boukhechba, Elise Verron, Myriam LeFerrec, Gilles Montavon, Julie Lesoeur, Verena Schnitzler, Dominique Massiot, Pascal Janvier, Olivier Gauthier, Jean-Michel Bouler, Bruno Bujoli
초록

Different possible options were investigated to combine an apatitic calcium phosphate cement with gallium ions, known as bone resorption inhibitors. Gallium can be either chemisorbed onto calcium-deficient apatite or inserted in the structure of β-tricalcium phosphate, and addition of these gallium-doped components into the cement formulation did not significantly affect the main properties of the biomaterial, in terms of injectability and setting time. Under in vitro conditions, the amount of gallium released from the resulting cement pellets was found to be low, but increased in the presence of osteoclastic cells. When implanted in rabbit bone critical defects, a remodeling process of the gallium-doped implant started and an excellent bone interface was observed. The integration of drugs and materials is a growing force in the medical industry. The incorporation of pharmaceutical products not only promises to expand the therapeutic scope of biomaterials technology but to design a new generation of true combination products whose therapeutic value stem equally from both the structural attributes of the material and the intrinsic therapy of the drug. In this context, for the first time an injectable calcium phosphate cement containing gallium was designed with properties suitable for practical application as a local delivery system, implantable by minimally invasive surgery. This important and original paper reports the design and in-depth chemical and physical characterization of this groundbreaking technology.

MATERIALS
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Sigma-Aldrich
Nitric-14N acid solution, ~10 N in H2O, 99.99 atom % 14N
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Acetone, ≥99%, meets FCC analytical specifications
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Acetone, natural, ≥97%
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Gallium, 99.9995% trace metals basis
Sigma-Aldrich
Gallium, 99.99% trace metals basis
Sigma-Aldrich
Gallium, 99.999% trace metals basis
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Allyl methyl sulfone, 96%
Sigma-Aldrich
Nitric acid, ACS reagent, ≥90.0%
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Nitric acid, 70%, purified by redistillation, ≥99.999% trace metals basis
Sigma-Aldrich
Gallium(III) nitrate hydrate, crystalline, 99.9% trace metals basis
Sigma-Aldrich
Gallium(III) nitrate hydrate, crystals and lumps, 99.999% trace metals basis