Relative resistance of rabbits to MPTP neurotoxicity.

Relative resistance of rabbits to MPTP neurotoxicity.

Molecular and chemical neuropathology (1995-06-01)

N Lermontova, O Drany, D Dobrota, V Mezesova, V Lombardi, S Bachurin

초록

The neurotoxic actions of MPTP and its 4-(O-tolyl) analog (2'-Me-MPTP) on two breeds of rabbits were investigated. MPTP, but not 2'-Me-MPTP, causes a reduction (about 40%) in striatal dopamine content in rabbits of the "little silver-black" breed. The dopamine content of striata of "chinchilla" rabbits was not affected by either agent.

MATERIALS

제품 번호

브랜드

제품 설명

M103

Sigma-Aldrich

1-Methyl-4-(2′-methylphenyl)-1,2,3,6-tetrahydropyridine hydrochloride, solid