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Merck
  • Gamma-butyrolactone and furan signaling systems in Streptomyces.

Gamma-butyrolactone and furan signaling systems in Streptomyces.

Methods in enzymology (2012-10-23)
John D Sidda, Christophe Corre
초록

Streptomyces bacteria produce different classes of diffusible signaling molecules that trigger secondary metabolite production and/or morphological development within the cell population. The biosynthesis of gamma-butyrolactones (GBLs) and 2-alkyl-4-hydroxymethylfuran-3-carboxylic acids (AHFCAs) signaling molecules is related and involves an essential AfsA-like butenolide synthase. This chapter first describes the catalytic role of AfsA-like enzyme then provides details about methods for the discovery and characterization of potentially novel signaling molecules. In section 4, one approach for establishing the biological role of these signaling molecules is presented.

MATERIALS
제품 번호
브랜드
제품 설명

Sigma-Aldrich
Furan, ≥99%
Sigma-Aldrich
Dihydroxyacetone phosphate hemimagnesium salt hydrate, ≥95% (TLC)