์ฝ˜ํ…์ธ ๋กœ ๊ฑด๋„ˆ๋›ฐ๊ธฐ
Merck

Intestinal alpha-glucosidase inhibitors: abdominal gas cysts.

Prescrire international (2012-09-29)
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Detailed imaging studies of gas cysts in the intestinal mucosa (pneumatosis cystoides intestinalis) have been reported in around 20 patients taking acarbose, miglitolor voglibose, i.e. intestinal alpha-glucosidase inhibitors used as hypoglycaemic agents. Almost all the patients had nonspecific abdominal symptoms such as abdominal pain, abdominal distension, rectal bleeding or loss of appetite. They underwent multiple diagnostic tests before a role of the drug was raised. The disorders resolved completely when the drugs were withdrawn. In practice, as acarbose and miglitol have no proven impact on morbidity or mortality, and as they have multiple adverse effects, including gas cysts, they should not be used to treat diabetic patients.

MATERIALS
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Sigma-Aldrich
1-Deoxynojirimycin hydrochloride
Sigma-Aldrich
Voglibose, ≥97.0% (TLC)
Sigma-Aldrich
Acarbose, ≥95% (HPLC)
Sigma-Aldrich
Miglitol
Supelco
Acarbose, Pharmaceutical Secondary Standard; Certified Reference Material