U106
(−)-cis-(1S,2R)-U-50488 tartrate
solid
동의어(들):
(−)-(1S,2R)-cis-3,4-Dichloro-N-methyl-N-[2-(1-pyrrolidinyl)cyclohexyl]benzeneacetamide tartrate
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H26Cl2N2O · C4H6O6
CAS Number:
Molecular Weight:
519.42
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
양식
solid
색상
white
solubility
ethanol: soluble
저장 온도
2-8°C
SMILES string
OC(C(O)C(O)=O)C(O)=O.CN([C@H]1CCCC[C@H]1N2CCCC2)C(=O)Cc3ccc(Cl)c(Cl)c3
InChI
1S/C19H26Cl2N2O.C4H6O6/c1-22(19(24)13-14-8-9-15(20)16(21)12-14)17-6-2-3-7-18(17)23-10-4-5-11-23;5-1(3(7)8)2(6)4(9)10/h8-9,12,17-18H,2-7,10-11,13H2,1H3;1-2,5-6H,(H,7,8)(H,9,10)/t17-,18+;/m0./s1
InChI key
DMBKHRMAGYYBJM-CJRXIRLBSA-N
유전자 정보
human ... OPRS1(10280)
생화학적/생리학적 작용
Potent σ receptor ligand.
제조 메모
(-)-cis-(1S,2R)-U-50488 tartrate is soluble in ethanol.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
가장 최신 버전 중 하나를 선택하세요:
K Rasakham et al.
Neuroscience, 223, 447-456 (2012-08-07)
Recently there has been a widespread interest in the development of kappa opioid receptor (KOPR) ligands for treatment of pain, depression and anxiety, and prevention of stress-induced drug relapse. However, most of these preclinical studies have been conducted using male
Q-Schick Auh et al.
Neuroscience letters, 524(2), 111-115 (2012-07-24)
Activation of peripheral κ opioid receptors (KOR) effectively relieves pain and hyperalgesia in preclinical and clinical models of pain. Although centrally located KOR activation results in sexually dimorphic effects, it is unclear whether peripheral KOR also produces sex dependent effects
A A Spasov et al.
Eksperimental'naia i klinicheskaia farmakologiia, 74(8), 45-47 (2012-01-12)
A new model is proposed for in vitro testing the efficiency of new chemical substances with kappa-opioid receptor agonist ligand properties.
Amber D Shaffer et al.
Neuroscience letters, 534, 150-154 (2012-12-04)
Previous research has suggested that early-in-life (EIL) exposure to bladder inflammation impairs the function of endogenous opioid inhibitory system(s) and may contribute to the development of chronic bladder pain. This study examined how acute adult and/or prior EIL exposure to
Yu-Wei Chen et al.
Alcohol (Fayetteville, N.Y.), 47(1), 31-38 (2012-12-04)
The opioid system is known to enhance motivated behaviors, including ethanol drinking and food ingestion, by acting in various reward-related brain regions, such as the nucleus accumbens, ventral tegmental area and medial hypothalamus. There is indirect evidence, however, suggesting that
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