추천 제품
![(3R,5R,6S,7R,14S)-12-[(2,6-DIDEOXY-3-O-METHYL-ALPHA-L-GLYCERO-HEXOPYRANOSYL)OXY]-6-HYDROXY-5,7,8,11,13,15-HEXAMETHYL-4,10-DIOXO-1,9-DIOXASPIRO[2.13]HEXADEC-14-YL 3,4,6-TRIDEOXY-3-(DIMETHYLAMINO)-D-GLYCERO-HEXOPYRANOSIDE AldrichCPR](/deepweb/assets/sigmaaldrich/product/structures/173/328/834e3009-73db-49dd-86d3-42170cf81f5a/640/834e3009-73db-49dd-86d3-42170cf81f5a.png)
동작 모드
enzyme | inhibits
protein synthesis | interferes
SMILES string
CO[C@H]1C[C@@H](O[C@@H](C)[C@@H]1OC(C)=O)O[C@H]2[C@H](C)[C@@H](O[C@@H]3O[C@H](C)C[C@@H]([C@H]3OC(C)=O)N(C)C)[C@@H](C)C[C@@]4(CO4)C(=O)[C@H](C)[C@@H](OC(C)=O)[C@@H](C)[C@@H](C)OC(=O)[C@@H]2C
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일반 설명
Chemical structure: macrolide
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 2
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
Soo H Bae et al.
The Journal of pharmacy and pharmacology, 61(12), 1637-1642 (2009-12-05)
It has been reported that hepatic cytochrome P450 (CYP)2C9 and CYP3A4 are responsible for the metabolism of sildenafil and formation of its metabolite, N-desmethylsildenafil, in humans. However, in-vivo studies in rats have not been reported. Sildenafil (20 mg/kg) was administered
Güliz Gürel et al.
Antimicrobial agents and chemotherapy, 53(12), 5010-5014 (2009-09-10)
Structures have been obtained for the complexes that triacetyloleandomycin and mycalamide A form with the large ribosomal subunit of Haloarcula marismortui. Triacetyloleandomycin binds in the nascent peptide tunnel and inhibits the activity of ribosomes by blocking the growth of the
Daniel R Albaugh et al.
Drug metabolism and disposition: the biological fate of chemicals, 40(7), 1336-1344 (2012-04-12)
The current studies assessed the utility of freshly plated hepatocytes, cryopreserved plated hepatocytes, and cryopreserved plated HepaRG cells for the estimation of inactivation parameters k(inact) and K(I) for CYP3A. This was achieved using a subset of CYP3A time-dependent inhibitors (fluoxetine
Shobana Ganesan et al.
Toxicology and applied pharmacology, 241(1), 14-22 (2009-07-21)
Primaquine, an 8-aminoquinoline, is the drug of choice for radical cure of relapsing malaria. Use of primaquine is limited due to its hemotoxicity, particularly in populations with glucose-6-phosphate dehydrogenase deficiency [G6PD(-)]. Biotransformation appears to be central to the anti-infective and
Yuan Chen et al.
Drug metabolism and disposition: the biological fate of chemicals, 39(11), 2085-2092 (2011-08-13)
Assessment of time-dependent inhibition (TDI), especially CYP3A4, is an important parameter for preclinical and clinical development. The use of human liver microsomes (HLM) is the most common in vitro matrix to assess TDI, but this often leads to an overprediction
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