모든 사진(1)
About This Item
실험식(Hill 표기법):
C16H14N2
CAS Number:
Molecular Weight:
234.30
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
분석
≥98%
solubility
0.1 M HCl: soluble <1 mg/mL
ethanol: soluble 10 mg/mL
methylene chloride: soluble 10 mg/mL
0.1 M NaOH: insoluble
2-hydroxypropyl-β-cyclodextrin: insoluble
H2O: insoluble
저장 온도
−20°C
SMILES string
Cc1cc2ncc(nc2cc1C)-c3ccccc3
유전자 정보
human ... EGFR(1956) , FLT3(2322) , PDGFRB(5159) , SRC(6714)
mouse ... Pdgfrb(18596)
애플리케이션
Tyrphostin AG 1295 has been used as an Flt3 inhibitor in NA10 and ND13 progenitor cell lines2. Studies using AG 1295 have reported that it can reduce cell division and DNA synthesis induced by nicotine in human aortic vascular smooth muscle cells3.
Tyrphostin AG 1295 is soluble in methylene chloride at 10 mg/ml, in ethanol at 10 mg/ml and in 0.1 N HCl at less than 1 mg/ml. It is however, insoluble in water, 0.1 N sodium hydroxide, and 2-hydroxypropyl-β-cyclodextrin.
생화학적/생리학적 작용
Studies in mouse osteoblastic MC3T3-E1 cells have reported that AG 1295 can enhance matrix mineralization and osteoblast differentiation by inhibiting PDGFR-β signaling4.
Selective inhibitor of tyrosine kinase in platelet-derived growth factor (PDGF) receptor.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ivo A Pestana et al.
Journal of cellular biochemistry, 96(5), 986-995 (2005-09-09)
Cigarette smoking is implicated in the formation of occlusive vascular diseases. Nicotine's role in this process is incompletely understood. Nicotine's effect on human aortic vascular smooth muscle cells (HaVSMC) and the role of the nicotinic receptor (nAChR), platelet-derived growth factor
Y Y Zhang et al.
Bioscience trends, 6(3), 130-135 (2012-08-15)
Previous studies have conflicting views on the effect of platelet-derived growth factor (PDGF)/PDGF receptor (PDGFR) signaling on osteogenesis. The current study investigated the effect of PDGF receptor-beta (PDGFR-β) inhibition by AG-1295 on the osteogenic differentiation of the mouse pre-osteoblastic cell
M Kovalenko et al.
Cancer research, 54(23), 6106-6114 (1994-12-01)
A novel class of tyrosine kinase blockers represented by the tyrphostins AG1295 and AG1296 is described. These compounds inhibit selectively the platelet-derived growth factor (PDGF) receptor kinase and the PDGF-dependent DNA synthesis in Swiss 3T3 cells and in porcine aorta
Lars Palmqvist et al.
Blood, 108(3), 1030-1036 (2006-07-25)
In leukemogenesis, several genetic changes conferring a proliferative and/or survival advantage to hematopoietic progenitor cells in addition to a block in differentiation are required. Here, we demonstrate that overexpression of the wild-type (wt) Flt3 receptor tyrosine kinase collaborates with NUP98-HOX
Junichi Kasuya et al.
Journal of tissue engineering and regenerative medicine, 9(3), 247-256 (2012-10-23)
In liver sinusoids, hepatic stellate cells (HSCs) locate the outer surface of microvessels to form a functional unit with endothelia and hepatocytes. To reconstruct functional liver tissue in vitro, formation of the HSC-incorporated sinusoidal structure is essential. We previously demonstrated
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