모든 사진(1)
About This Item
실험식(Hill 표기법):
C18H23IN2O2
CAS Number:
Molecular Weight:
426.29
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
형태
solid
색상
white
solubility
H2O: soluble
ethanol: soluble
저장 온도
−20°C
SMILES string
[I-].C[N+]1(C)C2CCC1CC(C2)OC(=O)c3c[nH]c4ccccc34
유전자 정보
human ... HTR3A(3359) , HTR3B(9177) , HTR3C(170572) , HTR3D(200909) , HTR3E(285242)
애플리케이션
3-Tropanylindole-3-carboxylate methiodide was used to study the role of 5-HT3 receptor-mediated cell signaling in mouse interstitial cells of Cajal and in cocaine-induced aggressive behavior in hamsters.
생화학적/생리학적 작용
3-Tropanylindole-3-carboxylate methiodide is an antagonist of 5-HT3 receptor that has antiemetic effects. It modulates the pacemaker activities of the mouse small intestine cells. It regulates the aggressive behavior induced by cocaine in hamsters.
Storage Class Code
13 - Non Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
개인 보호 장비
Eyeshields, Gloves, type N95 (US)
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
[3H]quaternised ICS 205-930 labels 5-HT3 receptor binding sites in rat brain.
K J Watling et al.
European journal of pharmacology, 149(3), 397-398 (1988-05-10)
Pawan Kumar Shahi et al.
The Korean journal of physiology & pharmacology : official journal of the Korean Physiological Society and the Korean Society of Pharmacology, 15(3), 129-135 (2011-08-24)
In this study we determined whether or not 5-hydroxytryptamine (5-HT) has an effect on the pacemaker activities of interstitial cells of Cajal (ICC) from the mouse small intestine. The actions of 5-HT on pacemaker activities were investigated using a whole-cell
K J Watling et al.
European journal of pharmacology, 182(3), 465-472 (1990-07-17)
Clozapine, an atypical neuroleptic drug devoid of extrapyramidal side effects, was a moderately potent, competitive inhibitor of the binding of [3H]quaternised ICS 205-930 to 5-HT3 receptor sites in rat cortical membranes, possessing a pKi value of 7.0. In contrast, several
Lesley A Ricci et al.
Behavioural brain research, 156(1), 19-29 (2004-10-12)
Hamsters repeatedly exposed to cocaine during adolescence display high levels of offensive aggression compared to saline-treated littermates. The escalated offensive phenotype observed in adolescent cocaine-treated animals is modulated by serotonin (5-HT) signaling and can be suppressed by inhibiting 5-HT type
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