SRP6399

IL-2 R beta/CD122 human

recombinant, expressed in HEK 293 cells, ≥90% (SDS-PAGE)

• 동의어(들): IL2RB, P70-75, RP5-1170K4.6
• UNSPSC 코드: 12352202

속성

• 생물학적 소스: human
• 재조합: expressed in HEK 293 cells
• 태그: 6-His tagged (C-terminus)
• 분석: ≥90% (SDS-PAGE)
• 양식: lyophilized
• 분자량: calculated mol wt 25.4 kDa; observed mol wt 40 kDa (DTT-reduced. Protein migrates due to glycosylation. Ala 27 is the predicted N-terminus.)
• 포장: pkg of 10 μg
• 불순물: <1 EU/μg endotoxin (LAL test)
• UniProt 수납 번호: P14784
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... IL2RB(3560)

설명

일반 설명

Interleukin-2 receptor (IL-2R)/ cluster of differentiation 122 (CD122) is a heterotrimeric protein, encoded by the gene mapped to human chromosome 22q12.3. The encoded protein is expressed on the surface of certain immune cells, such as lymphocytes, that binds and responds to a cytokine called IL-2. The IL-2R is made up of 3 subunits - α (CD25), β (CD122) and γ (CD132) - non-covalently associating. The α subunit is involved in binding IL-2, while signal transduction following cytokine interaction is carried out by the γ-chain, along with the β subunit. IL2R β is a member of the type I cytokine receptor family.

애플리케이션

Interleukin 2 receptor subunit β (IL2RB)/cluster of differentiation 122 (CD122) human has been used to study the effect of this cytokine on the expression of Klf15 in neurons.

생화학적/생리학적 작용

Interleukin 2 receptor subunit β (IL2RB) is involved in signal transduction via its ligand interleukin-2. It is also implicated in inflammation. Cluster of differentiation 122 (CD122) is the receptor for interleukin-2 and is involved in receptor mediated endocytosis and transduces the mitogenic signals of IL2.

물리적 형태

Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.

재구성

Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable