추천 제품
생물학적 소스
human
재조합
expressed in HEK 293 cells
태그
6-His tagged (C-terminus)
분석
≥95% (SDS-PAGE)
형태
lyophilized
분자량
calculated mol wt 23.2 kDa
observed mol wt 33-48 kDa (DTT-reduced. Protein migrates due to glycosylation. Ser 23 is the predicted N-terminus.)
포장
pkg of 10 μg
pkg of 50 μg
불순물
<1 EU/μg endotoxin (LAL test)
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
human ... SLAMF7(57823)
일반 설명
Research area: IMMUNO AND CKS
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. SLAM F7 (signaling lymphocytic activation molecule F7) receptors are expressed on immune cells such as activated T cells, most B cells, antibody-producing plasma cells and natural killer cells and also on myeloid cells. The SLAMF7 gene is mapped to human chromosome 1q23.3.
SLAM family member 7 (SLAMF7) is also known as CD2-like receptor-activating cytotoxic cells (CRACC), membrane protein FOAP-12, CD antigen CD319, Novel Ly9, Protein 19A, which is a single-pass type I membrane protein and a member of the CD2 family of cell surface receptors. SLAMF7 is expressed in spleen, lymph node, peripheral blood leukocytes, bone marrow, small intestine, stomach, appendix, lung and trachea. SLAM F7 (signaling lymphocytic activation molecule F7) receptors are expressed on immune cells such as activated T cells, most B cells, antibody-producing plasma cells and natural killer cells and also on myeloid cells. The SLAMF7 gene is mapped to human chromosome 1q23.3.
생화학적/생리학적 작용
SLAMF7 (signaling lymphocytic activation molecule F7) is considered as a self-ligand which identifies another SLAMF7 expressed on the cell. Apart from immune cells, SLAMF7 is highly expressed in multiple myeloma cells.Isoform 1 of SLAMF7 mediates natural killer (NK) cell activation through a SH2 domain containing 1A (SH2D1A)-independent extracellular signal-regulated extracellular signal-regulated kinases (ERK) mediated pathway. It may play a role in lymphocyte adhesion.Isoform 3 of SLAMF7 does not mediate any NK cell activation.
물리적 형태
Lyophilized from 0.22 μm filtered solution in PBS, pH7.4. Generally 5-8% Mannitol or trehalose is added as a protectant before lyophilization.
재구성
Centrifuge the vial prior to opening. Reconstitute in sterile PBS, pH 7.4 to a concentration of 50 μg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 month. For extended storage, it is recommended to store at -20°C.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Controlling natural killer cell responses: integration of signals for activation and inhibition.
Long E O, et al.
Annual Review of Immunology, 31, 227-258 (2013)
Immune cell inhibition by SLAMF7 is mediated by mechanism requiring Src kinases, CD45 and SHIP-1 defective in multiple myeloma cells.
Guo H, et al.
Molecular and Cellular Biology (2014)
Elotuzumab and daratumumab: emerging new monoclonal antibodies for multiple myeloma.
Kuroda J, et al.
Expert Review of Anticancer Therapy, 13(9), 1081-1088 (2013)
Epigenetic suppression of the immunoregulator MZB1 is associated with the malignant phenotype of gastric cancer.
Kanda M, et al.
International Journal of Cancer. Journal International Du Cancer, 139(10), 2290-2298 (2016)
SLAM receptors and SAP influence lymphocyte interactions, development and function.
Schwartzberg P L, et al.
Nature Reviews: Immunology, 9(1), 39-39 (2009)
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