SRP6214

EGF Receptor human

recombinant, expressed in CHO cells, ≥95% (SDS-PAGE)

• 동의어(들): ErbB1
• UNSPSC 코드: 12352200

속성

• 생물학적 소스: human
• 재조합: expressed in CHO cells
• 분석: ≥95% (SDS-PAGE)
• 형태: lyophilized powder
• 분자량: 97.5 kDa
• 불순물: <1 EU/μg endotoxin (LAL test)
• UniProt 수납 번호: P01133
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... EGFR(1950)

설명

일반 설명

EGF Receptor (EGFR, ErbB1) is a transmembrane protein that exerts tyrosine kinase activity upon ligand induced activation. EGFR can be activated by binding EGF or at least six other structurally related protein ligands, including TGFα, HBEGF, βcellulin (BTC), Amphiregulin, Epiregulin, and Epigen. Upon activation, EGFR initiates a signaling cascade which includes dimerization and internalization, tyrosine phosphorylation, DNA synthesis of target genes, and, ultimately, cell proliferation. EGFR signaling plays a role in the growth and differentiation of normal cells, but elevated EGFR activity is correlated with the development and pathogenesis of certain cancers. Recombinant soluble human EGFR is a 621 amino acid glycoprotein comprising the extracellular domain of EGFR, and migrates at an apparent MW of 97.5 kDa by SDS-PAGE analysis under reducing conditions.

물리적 형태

Sterile filtered through a 0.2 micron filter. Lyophilized from 10 mM Sodium Phosphate, pH 7.5.

재구성

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable