SRP6212

sDLL-1 human

recombinant, expressed in HEK 293 cells, ≥95% (SDS-PAGE)

• 동의어(들): Delta-1, Delta-like protein 1
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in HEK 293 cells
• 분석: ≥95% (SDS-PAGE)
• 형태: lyophilized powder
• 분자량: 57-60 kDa
• 포장: pkg of 10 μg; pkg of 50 μg
• 불순물: <1 EU/μg endotoxin (LAL test)
• UniProt 수납 번호: O00548
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... DLL-1(28514)

설명

일반 설명

Human sDLL-1 comprises the extracellular signaling domain of DLL-1, a member of a structurally-related family of single-pass type I transmembrane proteins that serve as ligands for Notch receptors. It is expressed in the heart and pancreas, and to a lesser extent in various other tissues. Recombinant human sDLL-1 is a 57.0-60.0 kDa glycoprotein containing 522 amino-acid residues. The DLL-1 gene is mapped to human chromosome 6q27.

생화학적/생리학적 작용

DLL-1 (delta-like ligand 1) functions to specifically activate the Notch-1 and Notch-2 receptors. The Notch signaling pathway regulates endothelial-cell differentiation, proliferation and apoptosis, and is essential for the development, maintenance and remodeling of the vascular system. DLL-1 suppresses differentiation of hematopoietic progenitor cells into the B-cell lineage while promoting differentiation to T-cell and NK (natural killer) cell precursors. Upregulation of DLL-1 was observed in choriocarcinoma and hepatocellular carcinoma.

물리적 형태

Sterile filtered through a 0.2 micron filter. Lyophilized from 1X PBS, pH 7.5.

재구성

Centrifuge the vial prior to opening. Reconstitute in water to a concentration of 0.1-1.0 mg/mL. Do not vortex. This solution can be stored at 2-8°C for up to 1 week. For extended storage, it is recommended to further dilute in a buffer containing a carrier protein (example 0.1% BSA) and store in working aliquots at -20°C to -80°C.

안전성 정보

• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable