재조합
expressed in baculovirus infected Sf9 cells
제품 라인
PRECISIO® Kinase
분석
≥70% (SDS-PAGE)
형태
buffered aqueous glycerol solution
특이 활성도
195-265 nmol/min·mg
분자량
~51 kDa
NCBI 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
human ... ULK3(25989)
일반 설명
The ULK3 (unc-51 like kinase 3) gene is mapped to human chromosome 15q24.1.
생화학적/생리학적 작용
ULK3 or unc-51-like kinase 3 is a member of the serine/threonine kinase family that is involved in the SHH signaling pathway as a positive regulator of GLI proteins. ULK3 enhances endogenous and over-expressed GLI transcriptional activity in cultured cells and alters its subcellular localization. Furthermore, ULK3 phosphorylates GLI proteins in vitro. ULK3 is widely expressed and its expression is higher in a number of tissues where SHH signaling is known to be active, again suggesting that ULK3 is involved in the SHH pathway as a positive regulator of GLI proteins. ULK3 participates in cell cycle checkpoint and prevents the progression of cell division prior to complete chromosome separation. Overexpression of ULK3 stimulates autophagy through fibroblast activation.
물리적 형태
Supplied in 50mM sodium phosphate, pH 7.0, 300mM NaCl, 150mM imidazole, 0.1mM PMSF, 0.25mM DTT, 25% glycerol.
제조 메모
after opening, aliquot into smaller quantities and store at -70 °C. Avoid repeating handling and multiple freeze/thaw cycles
법적 정보
PRECISIO is a registered trademark of Merck KGaA, Darmstadt, Germany
신호어
Danger
유해 및 위험 성명서
Hazard Classifications
Eye Irrit. 2 - Repr. 1B - Skin Irrit. 2
Storage Class Code
6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
WGK
WGK 1
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
ULK3 regulates cytokinetic abscission by phosphorylating ESCRT-III proteins
Caballe A, et al.
eLife, 4(10), e06547-e06547 (2015)
Novel genes affecting blood pressure detected via gene-based association analysis
Zhang H,et al.
Genes & Genomics, g3-115 (2015)
The ULK3 Kinase Is Critical for Convergent Control of Cancer-Associated Fibroblast Activation by CSL and GLI
Goruppi , et al.
Testing, 20(10), 2468-2479 (2017)
Alla Maloverjan et al.
Experimental cell research, 316(4), 627-637 (2009-11-03)
The Hedgehog (Hh) signaling pathway plays crucial roles in embryonic development and is implicated in tissue homeostasis maintenance and neurogenesis in adults. Aberrant activation of Hh signaling is associated with various developmental abnormalities and several types of cancer. Genetic and
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