생물학적 소스
mouse
재조합
expressed in E. coli
분석
≥90% (HPLC)
≥90% (SDS-PAGE)
형태
solution
분자량
~57 kDa
포장
pkg of 5 μg
저장 조건
avoid repeated freeze/thaw cycles
불순물
endotoxin, tested
NCBI 수납 번호
배송 상태
dry ice
저장 온도
−70°C
유전자 정보
mouse ... Calb2(12308)
일반 설명
Calretinin is a Ca2+-binding protein. It belongs to the EF-hand family. This gene is upregulated in reactive mesothelial cells and in malignant mesothelioma.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.
생화학적/생리학적 작용
Calretinin is widely distributed in the brain and might be responsible for neural protection. It regulates calcium signaling in neurons. Absence of calretinin in mice negatively affects long-term potentiation, motor coordination and Purkinje cell activity.
물리적 형태
50 ml (100 μg/ml) in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, 20% Glycerol.
재구성
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Storage Class Code
10 - Combustible liquids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
Journal of Neurochemistry, 123, 437-437 (2012)
Calretinin regulates Ca2+-dependent inactivation and facilitation of Ca(v)2.1 Ca2+ channels through a direct interaction with the a12.1 subunit.
The Journal of Biological Chemistry, 287, 39766-39766 (2012)
Frontiers in neuroanatomy, 14, 61-61 (2020-09-29)
Secretagogin (SCGN) which acts as a calcium signaling sensor, has previously been shown to be expressed by a substantial population of cortical GABAergic neurons at mid-gestation in humans but not in mice. The present study traced SCGN expression in cortical
Respiratory research, 16, 153-153 (2015-12-24)
The Ca(2+)-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin's likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus
The Journal of comparative neurology, 525(6), 1403-1420 (2016-03-15)
The tree shrew (Tupaia belangeri) striate cortex is reciprocally connected with the dorsal lateral geniculate nucleus (dLGN), the ventral pulvinar nucleus (Pv), and the claustrum. In the Pv or the dLGN, striate cortex projections are thought to either strongly "drive"
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