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Merck
모든 사진(1)

문서

SRP4809

Sigma-Aldrich

Calretinin from mouse

recombinant, expressed in E. coli, ≥90% (SDS-PAGE), ≥90% (HPLC)

동의어(들):

CR, Calb2, Calretinin, calbindin 2

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About This Item

UNSPSC 코드:
12352202

생물학적 소스

mouse

재조합

expressed in E. coli

분석

≥90% (HPLC)
≥90% (SDS-PAGE)

형태

solution

분자량

~57 kDa

포장

pkg of 5 μg

저장 조건

avoid repeated freeze/thaw cycles

불순물

endotoxin, tested

NCBI 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

mouse ... Calb2(12308)

일반 설명

Calretinin is a Ca2+-binding protein. It belongs to the EF-hand family. This gene is upregulated in reactive mesothelial cells and in malignant mesothelioma.
Recombinant mouse Calretinin protein is expressed from Escherichia coli and purified by proprietary chromatographic techniques.

생화학적/생리학적 작용

Calretinin is widely distributed in the brain and might be responsible for neural protection. It regulates calcium signaling in neurons. Absence of calretinin in mice negatively affects long-term potentiation, motor coordination and Purkinje cell activity.

물리적 형태

50 ml (100 μg/ml) in 50 mM Tris-Acetate, pH 7.5, 1 mM EDTA, 20% Glycerol.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Storage Class Code

10 - Combustible liquids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

Calretinin interacts with huntingtin and reduces mutant huntingtin-caused cytotoxicity.
Dong G, et al.
Journal of Neurochemistry, 123, 437-437 (2012)
Calretinin regulates Ca2+-dependent inactivation and facilitation of Ca(v)2.1 Ca2+ channels through a direct interaction with the a12.1 subunit.
Christel CJ, et al.
The Journal of Biological Chemistry, 287, 39766-39766 (2012)
Ayman Alzu'bi et al.
Frontiers in neuroanatomy, 14, 61-61 (2020-09-29)
Secretagogin (SCGN) which acts as a calcium signaling sensor, has previously been shown to be expressed by a substantial population of cortical GABAergic neurons at mid-gestation in humans but not in mice. The present study traced SCGN expression in cortical
Walter Blum et al.
Respiratory research, 16, 153-153 (2015-12-24)
The Ca(2+)-binding protein calretinin is currently used as a positive marker for identifying epithelioid malignant mesothelioma (MM) and reactive mesothelium, but calretinin's likely role in mesotheliomagenesis remains unclear. Calretinin protects immortalized mesothelial cells in vitro from asbestos-induced cytotoxicity and thus
Jonathan D Day-Brown et al.
The Journal of comparative neurology, 525(6), 1403-1420 (2016-03-15)
The tree shrew (Tupaia belangeri) striate cortex is reciprocally connected with the dorsal lateral geniculate nucleus (dLGN), the ventral pulvinar nucleus (Pv), and the claustrum. In the Pv or the dLGN, striate cortex projections are thought to either strongly "drive"

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