SRP4247

MIP-1beta human

recombinant, expressed in E. coli, ≥99% (SDS-PAGE), ≥99% (HPLC)

• 동의어(들): CCL4, MIP-1- β, Macrophage inflammatory protein 1-β, Small inducible cytokine A4, T-cell activation protein 2
• MDL number: MFCD00213005
• UNSPSC 코드: 12352200
• NACRES: NA.32

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥99% (HPLC); ≥99% (SDS-PAGE)
• 양식: lyophilized
• 분자량: ~7.6 kDa
• 포장: pkg of 10 μg
• 불순물: endotoxin, tested
• NCBI 수납 번호: P13236
• 배송 상태: wet ice
• 저장 온도: −20°C
• 유전자 정보: human ... CCL4(388372)

설명

일반 설명

MIP-1β (macrophage inflammatory protein-1β), or CCL4L1 (C-C motif chemokine ligand 4 like 1), is a CC chemokine gene localized to human chromosome 17q12. It is a copy number variable gene which shares 95% sequence homology with its non-copy number variable paralogues CCL4. MIP-1β is expressed by a wide range of cells including immune cells, such as monocytes, B and T cells, fibroblasts, endothelial, and epithelial cells.

생화학적/생리학적 작용

MIP-1β (macrophage inflammatory protein-1β), or CCL4L1 (C-C motif chemokine ligand 4 like 1), interacts with its major G protein-coupled receptors CCR5 and CCR8, and promotes the migration of immune cells, such as monocytes, natural killer (NK) cells, and T cells, maturation of dendritic cells (DCs), T cell and granulocyte activation, and T cell differentiation. It is an age associated inflammatory cytokine, and it shows elevated expression in the monocytes and blood of elderly individuals. MIP-1β plays a wide role in immune responses, and hence, its expression is tightly controlled during T-cell differentiation and activation.

물리적 형태

Lyophilized without any additives.

재구성

Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.

Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.