추천 제품
생물학적 소스
rat
재조합
expressed in E. coli
분석
≥95% (HPLC)
≥95% (SDS-PAGE)
양식
lyophilized
분자량
~7.69 kDa
포장
pkg of 20 μg
저장 조건
avoid repeated freeze/thaw cycles
불순물
endotoxin, tested
NCBI 수납 번호
UniProt 수납 번호
배송 상태
wet ice
저장 온도
−20°C
유전자 정보
rat ... Igf1(24482)
일반 설명
IGF-I (insulin-like growth factor-I) is a member of a family of polypeptide growth factors. Rat IGF-I is a 7.69kDa protein containing 70 amino acid residues.
IGF-I exists in two isoforms (IGF1A and IGF1B) in mouse due to alternative transcription.
애플리케이션
IGF-I (Insulin-like Growth Factor-I) from rat has been used to study the the effect of IGF-I, IL-27 (interleukin-27) and IL-35 on the blood flow in the inflamed joints of rats.
IGF-I from rat has also been used to test its effect on the expression of its receptor in rheumatoid arthritis model.
생화학적/생리학적 작용
IGF-I (Insulin-like growth factor-I) is a polypeptide growth factor that stimulates the proliferation of a wide range of cell types including muscle, bone and cartilage tissue. It mainly mediates growth and development. IGF-I is required for fetal growth and development. It is also involved in the growth and repair of heart tissues. IGF-I has been linked to neuroplasticity and hippocampal neurogenesis. It is important in the recovery from ischaemic injury.
IGF-I interacts with interleukins IL-27 and IL-35 and may play a role in chronic joint inflammation.
물리적 형태
Lyophilized without additives.
재구성
Centrifuge the vial prior to opening. Avoid freeze-thaw cycles.
Reconstitute in water to a concentration of 0.1-1.0 mg/mL. This solution can then be diluted into other aqueous buffers.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
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이미 열람한 고객
Glucose metabolism and hepatic Igf1 DNA methylation are altered in the offspring of dams fed a low-salt diet during pregnancy.
Siqueira FR
Physiology & Behavior, 154, 68-75 (2016)
Stefano Schiaffino et al.
Skeletal muscle, 1(1), 4-4 (2011-07-30)
A highly conserved signaling pathway involving insulin-like growth factor 1 (IGF1), and a cascade of intracellular components that mediate its effects, plays a major role in the regulation of skeletal muscle growth. A central component in this cascade is the
The effect of interleukins 27 and 35 and their role on mediating the action of insulin Like Growth Factor -1 on the inflammation and blood flow of chronically inflamed rat knee joint.
Houshmandi N
Cytokine, 81, 117-126 (2016)
María Llorens-Martín et al.
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry, 15(2), 134-148 (2009-03-25)
This review addresses the role of serum insulin-like growth factor 1 (IGF1) as one mechanism of adult neural plasticity, specifically, its regulation of hippocampal neurogenesis among other plasticity-related processes. It is suggested that IGF has been reused advantageously both for
He He et al.
Inflammation, 38(6), 2178-2184 (2015-06-25)
Sepsis-induced myocardial injury (SIMI) is caused by various mechanisms. The aim of this study was to investigate the effects of salidroside (Sal) on SIMI and its mechanisms in rats. The sepsis model was established by intraperitoneal injection of lipopolysaccharide (LPS)
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