SRP2163

Estrogen Receptor human

recombinant, expressed in insect cells, ≥80% (SDS-PAGE)

• 동의어(들): DKFZp686N23123, ER, ESR, ESRA, Era, NR3A1
• UNSPSC 코드: 12352200
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in insect cells
• 분석: ≥80% (SDS-PAGE)
• 양식: frozen liquid
• 분자량: ~68 kDa
• 포장: pkg of 4 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 200 μg/mL
• 색상: colorless to clear
• NCBI 수납 번호: NM_000125
• UniProt 수납 번호: P03372
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... ESR1(2099)

설명

일반 설명

The gene ESR1 (estrogen receptor-alpha) encodes a member of the superfamily of nuclear hormone receptors that are essential for the functioning of female reproductive system. The gene is mapped to human chromosome 6q25.

생화학적/생리학적 작용

Several members of the nuclear receptor family are directly associated with human malignancies including breast cancer, prostate cancer and leukemia. The pathogenesis of each of these diseases is underpinned by the activities of a member of the superfamily; estrogen receptor-alpha (ER alpha) in breast cancer, androgen receptor (AR) in prostate cancer, and retinoic acid receptor alpha (RAR alpha) in acute promyelocytic leukemia. Estrogen receptors (ER) are members of the superfamily of nuclear hormone receptors (2, 3) whose activity is required for the normal function of the female reproductive system. Two isoforms of estrogen receptor (ER α and ER β) have been described. They function as ligand-dependent transcriptional activators. The biological functions downstream of ER result from altered expression of direct transcriptional targets as well as secondary effects mediated by biological activities of direct targets. In the mammary gland, estrogen receptors regulate normal epithelial cell development and differentiation through their well-documented effects on transcription. Estrogens have long been known to have mitogenic functions in breast cancer cell lines and in breast tumors. Selective estrogen receptor modulatory compounds (SERMs), which bind directly to ER, can block the growth stimulatory function of estrogens.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable