SRP2051

HMG1, native from calf thymus

≥85% (SDS-PAGE)

• UNSPSC 코드: 12352200
• NACRES: NA.26

속성

• 생물학적 소스: bovine (calf) thymus
• 분석: ≥85% (SDS-PAGE)
• 형태: frozen liquid
• 분자량: ~24.9 kDa
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 900 μg/mL
• 기술: membrane array: suitable
• 색상: colorless to clear
• NCBI 수납 번호: X12796
• UniProt 수납 번호: P10103
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: bovine ... HMG1() , HMGB1(282691)

설명

생화학적/생리학적 작용

High mobility group 1 (HMG1) is a 26 kDa highly conserved non-sequence-specific DNA-binding nuclear protein. Mammalian HMG1 has two homologous DNA-binding domains HMG boxes, A and B (each of 80–90 amino-acid residues), linked by a short basic region to an acidic C-terminal domain containing 30 consecutive Asp and Glu residues. HMG1 has been implicated in a number of fundamental biological processes including transcription, replication and recombination, in which it plays a role in manipulating DNA structure by bending, looping, compaction or unwinding, or by directly contacting with distinct cellular proteins. HMG-1 can act as a repressor, by interacting with TBP to block pre-initiation complex formation or as an activator, by facilitating the binding of various transcription factors to their cognate DNA sequences. Most recently, it was discovered that HMG-1 is a late mediator of delayed endotoxin lethality by activating downstream cytokine release.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable