SRP2011

TFIIH, p62 subunit human

recombinant, expressed in E. coli, ≥70% (SDS-PAGE)

• 동의어(들): BTF2, TFB1, TFIIH
• UNSPSC 코드: 12352200
• NACRES: NA.26

속성

• 생물학적 소스: human
• 재조합: expressed in E. coli
• 분석: ≥70% (SDS-PAGE)
• 형태: frozen liquid
• 분자량: ~64.4 kDa
• 포장: pkg of 10 μg
• 저장 조건: avoid repeated freeze/thaw cycles
• 농도: 750 μg/mL
• 색상: clear colorless
• NCBI 수납 번호: NM_005316
• UniProt 수납 번호: P32780
• 배송 상태: dry ice
• 저장 온도: −70°C
• 유전자 정보: human ... GTF2H1(2965)

설명

생화학적/생리학적 작용

TFIIH, a multi-subunit complex is involved in several biological fundamental mechanisms of the cell: transcription, nucleotide excision repair and cell cycle regulation. p62 is one of the six subunits that constitutes the core of TFIIH. Analysis of the expression of the p62 gene reveals an over-expression in testis tissue. This subunit of TFIIH participates in a variety of protein-protein interactions. For example, Rb competes with TBP and p62 for binding to E2F thus repressing E2F-mediated trans-activation; herpes simplex virus VP16 and human p53 directly interact with the p62 subunit of TFIIH. In addition, TFIIH, via p62 phosphorylation is the major target for mitotic inactivation of transcription.

물리적 형태

Clear and colorless frozen liquid solution

제조 메모

Use a manual defrost freezer and avoid repeated freeze-thaw cycles. While working, please keep sample on ice.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable