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Merck
모든 사진(1)

Key Documents

SRP0254

Sigma-Aldrich

Cofilin 1 Active human

recombinant, expressed in E. coli, ≥90% (SDS-PAGE)

동의어(들):

CFL1, Cofilin, non-muscle isoform, p18

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About This Item

UNSPSC 코드:
12352202
NACRES:
NA.32

생물학적 소스

human

재조합

expressed in E. coli

분석

≥90% (SDS-PAGE)

형태

aqueous solution

분자량

44 kDa

포장

pkg of 200 μg

농도

>0.02 mg/mL

NCBI 수납 번호

UniProt 수납 번호

배송 상태

dry ice

저장 온도

−70°C

유전자 정보

human ... CFL1(1072)

일반 설명

Cofilin 1 is ubiquitously expressed and has a molecular mass of ~19kDa.
Human recombinant Cofilin1 (2-end) with N-terminal GST tag (GenBank Accession No. NM_005507), expressed in a E. coli expression system. Cofilin 1, MW = 44 kDa,
Human recombinant Cofilin1 (2-end) with N-terminal GST tag (GenBank Accession No. NM_005507), expressed in a E. coli expression system. Cofilin 1, MW = 44 kDa,

애플리케이션

Kinase substrate for the kinase assay; western blot

생화학적/생리학적 작용

Cofilin-l (CFL1) plays a vital role in the regulation of actin cytoskeleton reorganization. It is also implicated in cancer cell migration and invasion in several types of tumor tissues. Elevated expression of the gene is associated with the development of esophageal squamous cell carcinoma (ESCC). In addition, abnormal expression of the gene leads to vulvar cancer and thus, it can be considered as a potential therapeutic target for the same. CFL1 facilitates cytokinesis, cell motility and morphogenesis. Activated CFL1 helps in preventing cytoskeletal-associated defects in axonal development stimulated by Syns.

물리적 형태

Formulated in 25 mM Tris-HCl, pH 8.0, 100 mM NaCl, 0.05% Tween-20, 30% glycerol and 3 mM DTT.

제조 메모

Thaw on ice. Upon first thaw, briefly spin tube containing enzyme to recover full content of the tube. Aliquot enzyme into single use aliquots. Store remaining undiluted enzyme in aliquots at -70°C. Note: Enzyme is very sensitive to freeze/thaw cycles.

Storage Class Code

10 - Combustible liquids

WGK

WGK 1

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.

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문서 라이브러리 방문

Cofilin 1 activation prevents the defects in axon elongation and guidance induced by extracellular alpha-synuclein.
Tilve S
Scientific Reports (2015)
The role of cofilin-l in vulvar squamous cell carcinoma: A marker of carcinogenesis, progression and targeted therapy.
Wu Q
Oncology Reports, 35, 2743-2754 (2016)

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