SRE0021

Granzyme B human

recombinant, expressed in insect cells, ≥90% (SDS-PAGE)

• 동의어(들): Granzyme B human, Cytotoxic T-lymphocyte proteinase 2, Granzyme-2, GranzymeB, Lymphocyte protease, SECT, T-cell serine protease 1-3E
• UNSPSC 코드: 12352204
• NACRES: NA.32

속성

• 생물학적 소스: human
• Quality Level: 200
• 재조합: expressed in insect cells
• 분석: ≥90% (SDS-PAGE)
• 형태: lyophilized powder
• 효능: >0.004 units/mg
• 특이 활성도: ≥40 units/μg
• 포장: pkg of 5 μg
• UniProt 수납 번호: P10144
• 배송 상태: wet ice
• 저장 온도: −70°C
• 유전자 정보: human ... GZMB(3002)

설명

일반 설명

Granzyme B (GzmB) is a serine protease which is stored in granules of activated cytotoxic T cells and NK cells. GZMB codes for granzyme B.

생화학적/생리학적 작용

Granzyme B is considered as the marker of activated CTLs (cytotoxic T-cells), which mediates target-cell apoptosis. It induces apoptosis in caspase-dependent and caspase-independent manner. After contact with target cells, granzyme B is directionally exocytosed, and then enters the target cell with assistance from perforin. Granzyme B specifically cleaves after Asp residues, and particularly processes and activates various pro-caspases. This induces apoptosis in the target cell.

단위 정의

One unit is defined as the amount of enzyme that hydrolyzes 1 pmol/min of IETD-AFC per min at 37°C in 50 mM HEPES, pH 7.5 containing 10 mM CaCl₂.

물리적 형태

Lyophilized powder, containing HEPES buffer (original solution at pH 7.5)

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable