SML3045
XL177B
≥98% (HPLC)
동의어(들):
(R)-N-(4-benzyl-5-(4-hydroxy-4-((7-(3-(4-methylpiperazin-1-yl)propanamido)-4-oxoquinazolin-3(4H)-yl)methyl)piperidin-1-yl)-5-oxopentyl)-9-chloro-5,6,7,8-tetrahydroacridine-3-carboxamide
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C48H57ClN8O5
CAS Number:
Molecular Weight:
861.47
UNSPSC 코드:
12352200
NACRES:
NA.77
추천 제품
Quality Level
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=C1N(CC2(O)CCN(C([C@@H](CC3=CC=CC=C3)CCCNC(C4=CC(N=C(CCCC5)C5=C6Cl)=C6C=C4)=O)=O)CC2)C=NC7=CC(NC(CCN8CCN(C)CC8)=O)=CC=C71
생화학적/생리학적 작용
XL177B is a negative enantiomeric control for a cell penetrant, potent and highly selective covalent inhibitor of the deubiquitinating enzyme USP7 XL177A.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Nathan J Schauer et al.
Scientific reports, 10(1), 5324-5324 (2020-03-27)
Ubiquitin specific peptidase 7 (USP7) is a deubiquitinating enzyme (DUB) that removes ubiquitin tags from specific protein substrates in order to alter their degradation rate and sub-cellular localization. USP7 has been proposed as a therapeutic target in several cancers because
Jonathan W Bushman et al.
Cell chemical biology, 28(1), 78-87 (2020-10-03)
Deubiquitinating enzymes (DUBs) catalyze the removal of ubiquitin, thereby reversing the activity of E3 ubiquitin ligases and are central to the control of protein abundance and function. Despite the growing interest in DUBs as therapeutic targets, cellular functions for DUBs
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