추천 제품
분석
≥98% (HPLC)
형태
powder
색상
white to beige
solubility
DMSO: 2 mg/mL, clear
저장 온도
2-8°C
SMILES string
O=S(NC1C2=C(C=CC=C2)OC3=C1C=CC=C3)(C4=CC=C(C)C=C4)=O
InChI
1S/C20H17NO3S/c1-14-10-12-15(13-11-14)25(22,23)21-20-16-6-2-4-8-18(16)24-19-9-5-3-7-17(19)20/h2-13,20-21H,1H3
InChI key
OZCQEUZTOAAWDK-UHFFFAOYSA-N
관련 카테고리
생화학적/생리학적 작용
AH-7614 is a potent negative allosteric modulator (NAM) of the long-chain free fatty acid receptor FFA4 that prevents differentiation of a mouse mesenchymal stem cell line toward an adipocyte phenotype. AH-7614 (Compound 39) was first described as antagonist of FFA4 that blocks activation of FFA4 by polyunsaturated, ω-6 fatty acid, linoleic acid and GSK137647A.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Kenneth R Watterson et al.
Molecular pharmacology, 91(6), 630-641 (2017-04-08)
High-affinity and selective antagonists that are able to block the actions of both endogenous and synthetic agonists of G protein-coupled receptors are integral to analysis of receptor function and to support suggestions of therapeutic potential. Although there is great interest
Steven M Sparks et al.
Bioorganic & medicinal chemistry letters, 24(14), 3100-3103 (2014-06-03)
The exploration of a diarylsulfonamide series of free fatty acid receptor 4 (FFA4/GPR120) agonists is described. This work led to the identification of selective FFA4 agonist 8 (GSK137647A) and selective FFA4 antagonist 39. The in vitro profile of compounds 8
S Villegas-Comonfort et al.
Prostaglandins, leukotrienes, and essential fatty acids, 117, 1-10 (2017-02-27)
Arachidonic acid increased intracellular calcium, in cells expressing green fluorescent protein-tagged human FFA4 receptors, with an EC
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