SML1694

TVB-3166

≥98% (HPLC)

• 동의어(들): 4-(1-(5-(3,4-Dimethyl-1H-pyrazol-5-yl)-2,4-dimethylbenzoyl)azetidin-3-yl)benzonitrile
• 실험식(Hill 표기법): C₂₄H₂₄N₄O
• CAS Number: 1533438-83-3
• Molecular Weight: 384.47
• UNSPSC 코드: 41106300
• PubChem Substance ID: 329826022
• NACRES: NA.77

속성

• Quality Level: 100
• 분석: ≥98% (HPLC)
• 양식: powder
• 저장 조건: protect from light
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear (warmed)
• 저장 온도: 2-8°C
• SMILES string: CC1=C(C2=C(C)C(C)=NN2)C=C(C(N3CC(C4=CC=C(C#N)C=C4)C3)=O)C(C)=C1
• InChI: 1S/C24H24N4O/c1-14-9-15(2)22(10-21(14)23-16(3)17(4)26-27-23)24(29)28-12-20(13-28)19-7-5-18(11-25)6-8-19/h5-10,20H,12-13H2,1-4H3,(H,26,27)
• InChI key: ICDQFUFDAFKCAX-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis (IC₅₀ <100 nM) by fatty acid synthase (FASN) keto-reductase activity in a potent and reversible manner (IC₅₀ = 42 nM), effectively inhibiting palmitate-dependent survival of various cancer cells in cultures and xenografted tumor growth in mice vivo (60-100 mg/kg/d p.o.), while exhibiting little or no anti-proliferation activity toward non-palmitate-dependent growth of cancer and non-cancer cultures. FASN inhibition by TVB-3166 treatment is also effective against the replications respiratory viruses both in cultures (Effc. conc. 200 nM against RSV and PIV3 in A549, HEp2, and HeLa cultures) and in mice (50 mg/kg/12 h, p.o.; RSV) in vivo without significant adverse effects to the host cells or mice.

TVB-3166 is a cell-permeable pyrrazole derivative that inhibits cellular palmitate synthesis.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable