SML1361

BRD73954

≥98% (HPLC)

• 동의어(들): N-Hydroxy-N′-phenethyl-isophthalamide, N1-Hydroxy-N3-(2-phenylethyl)-1,3-benzenedicarboxamide, N1-Hydroxy-N3-phenethylisophthalamide
• 실험식(Hill 표기법): C₁₆H₁₆N₂O₃
• CAS Number: 1440209-96-0
• Molecular Weight: 284.31
• MDL number: MFCD26383435
• UNSPSC 코드: 12352202
• PubChem Substance ID: 329825816
• NACRES: NA.77

속성

• 분석: ≥98% (HPLC)
• 형태: powder
• 색상: white to light brown
• solubility: DMSO: 20 mg/mL, clear
• 저장 온도: 2-8°C
• SMILES string: ONC(C1=CC(C(NCCC2=CC=CC=C2)=O)=CC=C1)=O
• InChI: 1S/C16H16N2O3/c19-15(17-10-9-12-5-2-1-3-6-12)13-7-4-8-14(11-13)16(20)18-21/h1-8,11,21H,9-10H2,(H,17,19)(H,18,20)
• InChI key: FIHKWEQJEDRIFS-UHFFFAOYSA-N

설명

생화학적/생리학적 작용

BRD73954 is the first discovered histone deacetylase 6/8 dual inhibitor. BRD73954 has an IC₅₀ of 36 nM for the class IIb HDAC6 and 120 nM for the class I HDAC8 with IC₄₅₀′s ranging from 9 μM to greater than 33 μM for other HDACs.

안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable