SML1314

SAG dihydrochloride

≥98% (HPLC), lyophilized solid, smoothened (Smo) agonist

• 동의어(들): 3-Chloro-N-[trans-4-(methylamino)cyclohexyl]-N-[[3-(4-pyridinyl)phenyl]methyl]-benzo[b]thiophene-2-carboxamide dihydrochloride, Smoothened Agonist
• 실험식(Hill 표기법): C₂₈H₂₈ClN₃OS · 2HCl
• CAS Number: 912545-86-9
• Molecular Weight: 562.98
• UNSPSC 코드: 51111800
• PubChem Substance ID: 329825779
• NACRES: NA.77

속성

• product name: SAG dihydrochloride, ≥98% (HPLC)
• Quality Level: 100
• 분석: ≥98% (HPLC)
• 형태: lyophilized solid
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 20 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: O=C(C1=C(Cl)C2=C(C=CC=C2)S1)N([C@@]3([H])CC[C@@](NC)([H])CC3)CC4=CC(C5=CC=NC=C5)=CC=C4
• InChI: 1S/C28H28ClN3OS/c1-30-22-9-11-23(12-10-22)32(28(33)27-26(29)24-7-2-3-8-25(24)34-27)18-19-5-4-6-21(17-19)20-13-15-31-16-14-20/h2-8,13-17,22-23,30H,9-12,18H2,1H3/t22-,23-
• InChI key: VFSUUTYAEQOIMW-YHBQERECSA-N

설명

애플리케이션

Smoothened agonist (SAG) dihydrochloride has been used as a sonic hedgehog (SHH) pathway agonist:

• to study its effects on mouse hippocampal cells
• to determine its effects on the mitochondrial network in zebrafish embryo
• to study its effects on murine embryonic fibroblasts

생화학적/생리학적 작용

SAG is a potent and cell-permeable smoothened (Smo) agonist that activates Hedgehog pathway and counteracts Cyclopamine inhibition of Smo.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301,H413
• 예방조치 성명서: P264 - P270 - P273 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral - Aquatic Chronic 4
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable