SML1131

Fosbretabulin disodium

≥98% (HPLC)

• 동의어(들): 2-Methoxy-5-[(1Z)-2-(3,4,5-trimethoxyphenyl)ethenyl]phenyl disodium phosphate, CA4P, Combretastatin A4 phosphate disodium
• 실험식(Hill 표기법): C₁₈H₁₉O₈P · 2Na
• CAS Number: 168555-66-6
• Molecular Weight: 440.29
• MDL number: MFCD00943911
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825668

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: H₂O: 5 mg/mL, clear
• 저장 온도: −20°C
• SMILES string: [O-]P(OC1=CC(/C=C\C2=CC(OC)=C(OC)C(OC)=C2)=CC=C1OC)([O-])=O.[Na+].[Na+]
• InChI: 1S/C18H21O8P.2Na/c1-22-14-8-7-12(9-15(14)26-27(19,20)21)5-6-13-10-16(23-2)18(25-4)17(11-13)24-3;;/h5-11H,1-4H3,(H2,19,20,21);;/q;2*+1/p-2/b6-5-;;
• InChI key: VXNQMUVMEIGUJW-XNOMRPDFSA-L
• 유전자 정보: human ... TUBA1A(7846) , TUBA1B(10376) , TUBA1C(84790) , TUBA3C(7278) , TUBA3E(112714) , TUBA4A(7277) , TUBB(203068) , TUBB1(81027) , TUBB2A(7280) , TUBB2B(347733) , TUBB3(10381) , TUBB4A(10382) , TUBB4B(10383) , TUBB6(84617) , TUBB8(347688)

설명

생화학적/생리학적 작용

Fosbretabulin disodium (Combretastatin A4 phosphate, CA4P) is a potent vascular-disrupting agent (VDA). Fosbretabulin disodium is a prodrug that is converted to combretastatin A (Sigma Cat No. C7744) inside the endothelial cells that line blood vessels, where it binds to tubulin dimers and prevents microtubule polymerization, resulting in mitotic arrest and apoptosis in endothelial cells. Fosbretabulin disodium is a potent anti-cancer agent that exhibits antivascular effects on tumor vasculature, inducing a rapid reduction in tumor blood flow and a concomitant increase of cellular necrosis. Some of its activity is believed to involve interference with vascular endothelial-cadherin signaling in addition to its microtubule-disrupting activity.

Fosbretabulin disodium is a vascular disrupting agent; prodrug that is converted to combretastatin A inside the endothelial cells.

특징 및 장점

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안전성 정보

• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable