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Merck
모든 사진(1)

문서

SML0882

Sigma-Aldrich

Aurora-A Inhibitor I

≥98% (HPLC)

동의어(들):

TC‐S7010, N-(2-Chlorophenyl)-4-(2-(4-(2-(4-ethylpiperazin-1-yl)-2-oxoethyl)phenylamino)-5-fluoropyrimidin-4-ylamino)benzamide, N-(2-Chlorophenyl)-4-[[2-[[4-[2-(4-ethyl-1-piperazinyl)-2-oxoethyl]phenyl]amino]-5-fluoro-4-pyrimidinyl]amino]-benzamide

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모든 사진(1)

About This Item

실험식(Hill 표기법):
C31H31ClFN7O2
CAS Number:
1158838-45-9
Molecular Weight:
588.07
UNSPSC 코드:
12352200
NACRES:
NA.77

분석

≥98% (HPLC)

형태

powder

색상

white to beige

solubility

DMSO: 10 mg/mL, clear

저장 온도

2-8°C

InChI

1S/C31H31ClFN7O2/c1-2-39-15-17-40(18-16-39)28(41)19-21-7-11-24(12-8-21)36-31-34-20-26(33)29(38-31)35-23-13-9-22(10-14-23)30(42)37-27-6-4-3-5-25(27)32/h3-14,20H,2,15-19H2,1H3,(H,37,42)(H2,34,35,36,38)

InChI key

AKSIZPIFQAYJGF-UHFFFAOYSA-N

애플리케이션

Aurora-A Inhibitor I has been used to study its effect on cell viability of human megakaryoblastic cell line (SET-2) and human erythroleukemia cell line (HEL) by methylthiazoletetrazolium (MTT) assay.

생화학적/생리학적 작용

Aurora-A Inhibitor I is a potent inhibitor of Aurora kinase A with an IC50 of 3.4 nM and 1000-fold selectivity for Aurora A over Aurora B (better than VX-680) and even higher for CDKs. Antiproliferative IC50 values were in the vicinity of 1 μM against the human colorectal cancer cell line HCT116.
Aurora-A Inhibitor I, also known as TC‐S7010, stimulates G2/M cell cycle arrest and apoptosis in ARID1A −/− cells.

픽토그램

Exclamation mark
GHS07

신호어

Warning

유해 및 위험 성명서

H302

예방조치 성명서

P264 - P270 - P301 + P312 - P501

Hazard Classifications

Acute Tox. 4 Oral

Storage Class Code

11 - Combustible Solids

WGK

WGK 3

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable

시험 성적서(COA)

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문서 라이브러리 방문

Keli Lima et al.
Scientific reports, 9(1), 9895-9895 (2019-07-11)
JAK2/STAT signaling participates in the Ph-negative myeloproliferative neoplasms (MPN) pathophysiology and has been targeted by ruxolitinib, a JAK1/2 inhibitor. In the present study, the impact of ruxolitinib treatment on cytoskeleton-related genes expression was explored. In SET2 cells, AURKA and AURKB
Synthesis and structure elucidation of polyphenols containing the N'-methyleneformohydrazide scaffold as aurora kinase inhibitors.
Dongsoo Koh et al.
Magnetic resonance in chemistry : MRC, 55(9), 864-876 (2017-05-16)
Sandrine Baltzer et al.
International journal of molecular sciences, 23(2) (2022-01-22)
The cAMP-dependent aquaporin-2 (AQP2) redistribution from intracellular vesicles into the plasma membrane of renal collecting duct principal cells induces water reabsorption and fine-tunes body water homeostasis. However, the mechanisms controlling the localization of AQP2 are not understood in detail. Using
Changjie Wu et al.
Nature communications, 9(1), 3212-3212 (2018-08-12)
ARID1A, a component of the SWI/SNF chromatin remodeling complex, is a tumor suppressor with a high frequency of inactivating mutations in many cancers. Therefore, ARID1A deficiency has been exploited therapeutically for treating cancer. Here we show that ARID1A has a
Shoji Hata et al.
Nature cell biology, 21(9), 1138-1151 (2019-09-05)
One of the first steps in mitotic spindle assembly is the dissolution of the centrosome linker followed by centrosome separation driven by EG5, a tetrameric plus-end-directed member of the kinesin-5 family. However, even in the absence of the centrosome linker

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