SML0806

7DG

≥95% (HPLC)

• 동의어(들): 7-Desacetoxy-6,7-dehydrogedunin
• 실험식(Hill 표기법): C₂₆H₃₀O₅
• CAS Number: 26927-01-5
• Molecular Weight: 422.51
• UNSPSC 코드: 12352200
• NACRES: NA.77

속성

• 분석: ≥95% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 5 mg/mL, clear
• 배송 상태: wet ice
• 저장 온도: 2-8°C

설명

일반 설명

7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin.[1]

생화학적/생리학적 작용

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR).

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC₅₀) of 5 μM, showing a role for PKR in pyroptosis.

특징 및 장점

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H302
• 예방조치 성명서: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• Storage Class Code: 11 - Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable