SML0806

7DG

≥95% (HPLC)

• 동의어(들): 7-Desacetoxy-6,7-dehydrogedunin
• 실험식(Hill 표기법): C₂₆H₃₀O₅
• CAS 번호: 26927-01-5
• Molecular Weight: 422.51
• NACRES: NA.77
• UNSPSC Code: 12352200
• Assay: ≥95% (HPLC)
• Form: powder

속성

• Quality Segment: 100
• assay: ≥95% (HPLC)
• form: powder
• color: white to beige
• solubility: DMSO: 5 mg/mL, clear
• shipped in: wet ice
• storage temp.: 2-8°C

설명

General description

7-Desacetoxy-6,7-dehydrogedunin (7DG) is structurally similar to HSP90 (heat shock protein 90) inhibitor, also known as gedunin.

Biochem/physiol Actions

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR).

7-Desacetoxy-6,7-dehydrogedunin (7DG) is a selective inhibitor of protein kinase R (PKR). 7DG appears to directly interact with the C-terminal half of PKR, and unlike C16, does not bind the ATP catalytic pocket. 7-Desacetoxy-6,7-dehydrogedunin completely protected macrophages from anthrax lethal toxin (LT)-induced pyroptotic cell death, a model for inflammasome-mediated caspase-1 activation, with an (IC₅₀) of 5 μM, showing a role for PKR in pyroptosis.

Features and Benefits

This compound is featured on the Caspases page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 경고어: Warning
• 위험 코드: H302
• 주의 사항: P264 - P270 - P301 + P312 - P501
• Hazard Classifications: Acute Tox. 4 Oral
• 저장 등급: 11 - Combustible Solids
• WGK: WGK 3
• 인화점 (F): Not applicable
• 인화점 (°C): Not applicable