SML0555

ML289

≥98% (HPLC)

• 동의어(들): VU0463597, [(3R)-3-(Hydroxymethyl)-1-piperidinyl][4-[2-(4-methoxyphenyl)ethynyl]phenyl]-methanone
• 실험식(Hill 표기법): C₂₂H₂₃NO₃
• CAS Number: 1382481-79-9
• Molecular Weight: 349.42
• UNSPSC 코드: 12352200

속성

• 분석: ≥98% (HPLC)
• 양식: powder
• 색상: white to beige
• solubility: DMSO: 10 mg/mL, clear
• 저장 온도: 2-8°C
• InChI: 1S/C22H23NO3/c1-26-21-12-8-18(9-13-21)5-4-17-6-10-20(11-7-17)22(25)23-14-2-3-19(15-23)16-24/h6-13,19,24H,2-3,14-16H2,1H3/t19-/m1/s1
• InChI key: VSLWUPHHCFQTDB-LJQANCHMSA-N

설명

생화학적/생리학적 작용

ML289 (VU0463597) is a potent, selective and centrally penetrant negative allosteric modifier (NAM) of metabotropic glutamate receptor 3 (mGlu3). ML289 is >15-fold selective vs mGlu2 with an IC₅₀ value of 0.66 μM.

ML289 is a potent, selective and centrally penetrant negative allosteric modifier (NAM) of metabotropic glutamate receptor 3 (mGlu3).

특징 및 장점

This compound is featured on the Glutamate Receptors (G Protein Family) page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

안전성 정보

• 픽토그램: GHS07
• 신호어: Warning
• 유해 및 위험 성명서: H315,H319,H335
• 예방조치 성명서: P261 - P305 + P351 + P338
• Hazard Classifications: Eye Irrit. 2 - Skin Irrit. 2 - STOT SE 3
• Storage Class Code: 13 - Non Combustible Solids
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable