SML0508

Pentostatin

≥95% (HPLC)

• 동의어(들): (8R)-3-(2-Deoxy-β-D-erythro-pentofuranosyl)-3,4,7,8-tetrahydroimidazo[4,5-d][1,3]diazepin-8-ol, 2′-dCF, DCF, Deoxycoformycin
• 실험식(Hill 표기법): C₁₁H₁₆N₄O₄
• CAS Number: 53910-25-1
• Molecular Weight: 268.27
• UNSPSC 코드: 12352200
• PubChem Substance ID: 329825517
• NACRES: NA.77

속성

• 분석: ≥95% (HPLC)
• 형태: powder
• 광학 활성: [α]/D +70 to +80°, c = 1 in H₂O
• 저장 조건: desiccated
• 색상: white to beige
• solubility: H₂O: 10 mg/mL, clear
• 배송 상태: wet ice
• 저장 온도: −20°C
• SMILES string: OC[C@H]1O[C@H](C[C@@H]1O)n2cnc3[C@H](O)CN=CNc23
• InChI: 1S/C11H16N4O4/c16-3-8-6(17)1-9(19-8)15-5-14-10-7(18)2-12-4-13-11(10)15/h4-9,16-18H,1-3H2,(H,12,13)/t6-,7+,8+,9+/m0/s1
• InChI key: FPVKHBSQESCIEP-JQCXWYLXSA-N
• 유전자 정보: human ... ADA(100)

설명

애플리케이션

Pentostatin has been used in in vivo anti-tumor studies. It has also been used along with cyclophosphamide as a selective B-cell immune suppression regimen to explore solid tumor therapy by selectively targeting stromal endothelial cells.

생화학적/생리학적 작용

Pentostatin is a ring-expanded nucleoside (REN) that potently inhibits adenosine deaminase, which leads to lymphocyte toxicity. Pentostatin is used as anticancer agent to treat leukemia (hairy cell leukemia and chronic lymphocytic leukemia) and is investigated as an agent to treat graft-versus-host disease (GVHD).

Pentostatin/2′-deoxycoformycin is used to treat patients with Waldenström′s macroglobulinemia.

특징 및 장점

This compound is featured on the Adenosine Receptors page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.

기타 정보

Air sensitve; hygroscopic.

안전성 정보

• 픽토그램: GHS06
• 신호어: Danger
• 유해 및 위험 성명서: H301
• 예방조치 성명서: P264 - P270 - P301 + P310 - P405 - P501
• Hazard Classifications: Acute Tox. 3 Oral
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable