SML0431
PQ1 succinate
≥98% (HPLC)
동의어(들):
N1-[6-Methoxy-4-methyl-5-[3-(trifluoromethyl)phenoxy]-8-quinolinyl]-1,3-propanediamine butanedioic acid salt, PQ1 succinic acid salt
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모든 사진(1)
About This Item
실험식(Hill 표기법):
C25H28F3N3O6
CAS Number:
Molecular Weight:
523.50
MDL number:
UNSPSC 코드:
12352202
PubChem Substance ID:
NACRES:
NA.77
분석
≥98% (HPLC)
형태
powder
저장 조건
desiccated
색상
white to brown
solubility
DMSO: 15 mg/mL (clear solution)
저장 온도
2-8°C
SMILES string
OC(=O)CCC(O)=O.COc1cc(NCCCN)c2nccc(C)c2c1Oc3cccc(c3)C(F)(F)F
InChI
1S/C21H22F3N3O2.C4H6O4/c1-13-7-10-27-19-16(26-9-4-8-25)12-17(28-2)20(18(13)19)29-15-6-3-5-14(11-15)21(22,23)24;5-3(6)1-2-4(7)8/h3,5-7,10-12,26H,4,8-9,25H2,1-2H3;1-2H2,(H,5,6)(H,7,8)
InChI key
XFEIMRMBZQODRY-UHFFFAOYSA-N
생화학적/생리학적 작용
PQ1 binds tightly to connexin 43 and activates intracellular gap junctions. Treatment of the breast cancer cell line T47D with 200 nM PQ1 induces a 30% increase in gap junctional intercellularcommunication (GJIC) and a 90% decrease in cell growth, with no effect on normal breast epithelial cells.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Ying Ding et al.
Journal of cancer science & therapy, 4(11), 371-378 (2012-11-01)
Cisplatin is one of the most widely used anti-cancer drugs due to its ability to damage DNA and induce apoptosis. However, increasing reports of side effects and drug resistance indicate the limitation of cisplatin in cancer therapeutics. Recent studies showed
Ying Ding et al.
Apoptosis : an international journal on programmed cell death, 18(9), 1071-1082 (2013-05-17)
Apoptosis, a programmed cell death, is an important control mechanism of cell homeostasis. Deficiency in apoptosis is one of the key features of cancer cells, allowing cells to escape from death. Activation of apoptotic signaling pathway has been a target
Ying Ding et al.
Anti-cancer drugs, 23(9), 897-905 (2012-05-10)
Gap junctions are intercellular channels connecting adjacent cells, allowing cells to transport small molecules. The loss of gap junctional intercellular communication (GJIC) is one of the important hallmarks of cancer. Restoration of GJIC is related to the reduction of tumorigenesis
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