모든 사진(1)
About This Item
실험식(Hill 표기법):
C19H13NO4
CAS Number:
Molecular Weight:
319.31
MDL number:
UNSPSC 코드:
12352200
PubChem Substance ID:
NACRES:
NA.77
분석
≥98% (HPLC)
형태
powder
색상
orange
solubility
DMSO: ≥5 mg/mL (warmed to 60° C)
저장 온도
2-8°C
SMILES string
CCOC(=O)C1=C2c3ccccc3C(=O)c4cccc(NC1=O)c24
InChI
1S/C19H13NO4/c1-2-24-19(23)16-15-10-6-3-4-7-11(10)17(21)12-8-5-9-13(14(12)15)20-18(16)22/h3-9H,2H2,1H3,(H,20,22)
InChI key
UFJGFNHRMPMALC-UHFFFAOYSA-N
애플리케이션
NQDI-1 was used to study LPS-induced activation and role of ASK1 and p38 in anti-inflammatory cytokine production by macrophages.
생화학적/생리학적 작용
NQDI-1 inhibits the activation of caspase-3 and prevents cell death by apoptosis. It is neuroprotective and prevents the ROS-induced apoptosis of the neurons.
NQDI-1 is an inhibitor of apoptosis signal-regulating kinase (ASK1), Ki = 500 nM. NQDI-1 shows little or no inhibitory activity against Aurora A or ROCK kinases, or several receptor tyrosine kinases.
특징 및 장점
This compound is featured on the MAPKs page of the Handbook of Receptor Classification and Signal Transduction. To browse other handbook pages, click here.
Storage Class Code
11 - Combustible Solids
WGK
WGK 3
Flash Point (°F)
Not applicable
Flash Point (°C)
Not applicable
시험 성적서(COA)
제품의 로트/배치 번호를 입력하여 시험 성적서(COA)을 검색하십시오. 로트 및 배치 번호는 제품 라벨에 있는 ‘로트’ 또는 ‘배치’라는 용어 뒤에서 찾을 수 있습니다.
Youguang Luo et al.
Oncotarget, 7(46), 75155-75164 (2016-09-23)
Pancreatic cancer has an extremely grim prognosis, with an overall 5-year survival rate less than 5%, as a result of its rapid metastasis and late diagnosis. To combat this disease, it is crucial to better understand the molecular mechanisms that
So Yeong Cheon et al.
Frontiers in molecular neuroscience, 10, 261-261 (2017-09-01)
Inflammation is implicated in ischemic stroke and is involved in abnormal homeostasis. Activation of the immune system leads to breakdown of the blood-brain barrier and, thereby, infiltration of immune cells into the brain. Upon cerebral ischemia, infiltrated macrophages and microglia
Koji Nomura et al.
Neuroscience letters, 549, 163-167 (2013-06-08)
Reactive oxygen species (ROS) are believed to be involved in many forms of neurodegeneration, including ischaemic infarct damage and Alzheimer's disease. Despite the known involvement of p38 and JNK MAP kinases in mediating apoptosis and cell death in a variety
Xi Huang et al.
International journal of cancer, 146(7), 1963-1978 (2019-08-08)
E3 ubiquitin ligases primarily determine the substrate specificity of the ubiquitin-proteasome system and play an essential role in the resistance to bortezomib in multiple myeloma (MM). Neural precursor cell-expressed developmentally downregulated gene 4-1 (NEDD4-1, also known as NEDD4) is a
Aiko Tanaka et al.
Biochemical and biophysical research communications, 493(1), 468-473 (2017-09-09)
Free fatty acids not only play a role in cell membrane construction and energy production but also exert diverse cellular effects through receptor and non-receptor mechanisms. Moreover, epidemiological and clinical studies have so far suggested that polyunsaturated fatty acids (PUFAs)
문서
The mitogen-activated protein kinase (MAPK) family consists of stress-activated (SAPK) and MAPKs. Learn about their network of signal transduction cascades that mediate cellular responses to a diverse range of stimuli.
자사의 과학자팀은 생명 과학, 재료 과학, 화학 합성, 크로마토그래피, 분석 및 기타 많은 영역을 포함한 모든 과학 분야에 경험이 있습니다..
고객지원팀으로 연락바랍니다.