SBR00121

Amphotericin B water soluble

from semisynthetic, powder

• 동의어(들): AmB, Amphotericin
• 실험식(Hill 표기법): C₅₁H₈₂N₂O₁₉
• Molecular Weight: 1027.20
• UNSPSC 코드: 51302401

속성

• 생물학적 소스: fermentation/recombinant; semisynthetic
• Quality Level: 200
• 분석: ≥90% (HPLC)
• 형태: powder
• 저장 조건: protect from light
• 색상: light yellow to very dark yellow, to very dark brown
• 동작 모드: cell membrane | interferes
• 배송 상태: dry ice
• 저장 온도: −20°C
• 적합성: fungi; yeasts
• InChI: 1S/C47H73NO17/c1-27-17-15-13-11-9-7-5-6-8-10-12-14-16-18-34(64-46-44(58)41(48)43(57)30(4)63-46)24-38-40(45(59)60)37(54)26-47(61,65-38)25-33(51)22-36(53)35(52)20-19-31(49)21-32(50)23-39(55)62-29(3)28(2)42(27)56/h5-18,27-38,40-44,46,49-54,56-58,61H,19-26,48H2,1-4H3,(H,59,60)/b6-5+,9-7+,10-8+,13-11+,14-12+,17-15+,18-16+/t27-,28-,29-,30+,31+,32+,33-,34-,35+,36+,37-,38-,40+,41-,42+,43+,44-,46-,47+/m0/s1
• InChI key: APKFDSVGJQXUKY-INPOYWNPSA-N

설명

일반 설명

Amphotericin B is a polyene antifungal antibiotic which has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. Amphotericin B water soluble is a synthetic derivative of AmB that preserves the antifungal activity but is highly miscible in water up to 100 mg/mL.

생화학적/생리학적 작용

Mode of Action: Amphotericin B binds to sterols, forming pores in the membrane, and causing small molecules to leak out. Antimicrobial spectrum: Includes fungi and yeast It has a high affinity for sterols, especially ergosterols, of both fungal and bacterial cell membranes. It forms transmembrane channels by binding to sterols associated with membranes, thereby leading to the leakage of small molecules Amphotericin B elicits toxicity despite being an effective antibiotic for treating mycoses Normal usage in maintenance of antifungal cell cultures is 2.5 mg/L with penicillin and streptomycin used in the medium. Amphotericin B is most effective against fungi and yeast.

특징 및 장점

Easily soluble in water up to 100mg/mL
Animal component free
Tested for cell toxicity
Aseptically packaged
Can be 0.2µm filtered

제조 메모

Amphotericin B water soluble can be directly dissolved in the media to a working concentration of 2.5 mg/L.

기타 정보

Product is sensitive to light.

안전성 정보

• 픽토그램: GHS08
• 신호어: Danger
• 유해 및 위험 성명서: H372
• 예방조치 성명서: P260 - P264 - P270 - P314 - P501
• Hazard Classifications: STOT RE 1
• Storage Class Code: 6.1C - Combustible acute toxic Cat.3 / toxic compounds or compounds which causing chronic effects
• WGK: WGK 3
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable