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Merck
모든 사진(1)

문서

SBPVR4

Sigma-Aldrich

SB PREDIVEZ Reagent Kit for BCRP

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About This Item

UNSPSC 코드:
12161503

재조합

expressed in human cells

형태

liquid

배송 상태

dry ice

저장 온도

−70°C

일반 설명

SOLVO Biotechnology offers ready-to-use assay kits for efflux and uptake transporters. SOLVO′s PREDIVEZ Vesicular Transport Assay Kits are suitable for efflux transporter inhibition studies. The kits are designed to test the inhibitory effect of one or more test compounds on the vesicular transport of a probe substrate. In most cases a fluorescent probe substrate is included. Kits contain all reagents and solutions necessary to conduct the drug-transporter interaction assay of need.

애플리케이션

PREDIVEZ vesicular transport reagent Kit may be used for assessing human ATP binding cassette subfamily B member 1 (ABCB1) function and multidrug resistance-associated protein 2 (MRP2) efflux transporter function.
The PREDIVEZ Vesicular Transport Kit is a simple and powerful tool to investigate drug transporter interactions. It provides information on any interaction between the ABC transporter and the drug candidate that would affect the transport of the fluorescent or radiolabeled or cold.

PREDIVEZ vesicular transport kits contains buffers, probe substrate, and reference inhibitors needed to run vesicular transport assays (sufficient for 300 wells/kit –equivalent to existing 9-cpd PV kits). Assay protocol, calculation template, and example data file available on SOLVO website.

Transport membranes and control membranes are sold separately. This PREDIVEZ vesicular transport kit requires the transporter membranes and corresponding control membrane below:

SSB-BCRP-M-VT BCRP human membrane vesicles part number SBVT09-1EA and corresponding control membrane SB-M-CTRL part number SBCT02-1EA

SB-BCRP-HEK293-VT BCRP human membrane vesicles part number SBVT17-1EA and corresponding control membrane SB-HEK293-Mock-CTRL part number SBCT06-1EA

법적 정보

PREDIVEZ is a trademark of Solvo Biotechnology

픽토그램

CorrosionExclamation mark

신호어

Warning

유해 및 위험 성명서

Hazard Classifications

Met. Corr. 1 - Skin Sens. 1

Storage Class Code

8A - Combustible corrosive hazardous materials

Flash Point (°F)

188.6 °F

Flash Point (°C)

87 °C


시험 성적서(COA)

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문서 라이브러리 방문

Impact of probe compound in MRP2 vesicular transport assays
Kidron H , et al.
European Journal of Pharmaceutical Sciences, 46(1-2), 100-105 (2012)
ABCB1 transports Seliciclib (R-Roscovitine), a cyclin-dependent kinase inhibitor
Rajnai Z, et al.
Drug Metabolism and Disposition, dmd-110 (2010)

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