SAB5701928

Anti-Phospho-MLKL-S454 antibody produced in rabbit

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: rabbit
• Quality Level: 100
• 항체 생산 유형: primary antibodies
• 클론: polyclonal
• 형태: liquid
• 종 반응성: human, mouse
• 농도: 0.464 mg/mL
• 기술: western blot: 1:500-1:2000
• UniProt 수납 번호: Q8NB16
• 배송 상태: wet ice
• 저장 온도: −20°C
• 타겟 번역 후 변형: phosphorylation (pSer454)
• 유전자 정보: human ... Phospho-MLKL-S454(197259)

설명

일반 설명

This gene belongs to the protein kinase superfamily. The encoded protein contains a protein kinase-like domain; however, is thought to be inactive because it lacks several residues required for activity. This protein plays a critical role in tumor necrosis factor (TNF)-induced necroptosis, a programmed cell death process, via interaction with receptor-interacting protein 3 (RIP3), which is a key signaling molecule in necroptosis pathway. Inhibitor studies and knockdown of this gene inhibited TNF-induced necrosis. High levels of this protein and RIP3 are associated with inflammatory bowel disease in children. Alternatively spliced transcript variants have been described for this gene.

면역원

A phospho synthetic peptide corresponding to residues surrounding S454 of human MLKL.

물리적 형태

Buffer: PBS with 0.02% sodium azide,50% glycerol,pH7.3.

안전성 정보

• Storage Class Code: 12 - Non Combustible Liquids
• WGK: WGK 1
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable