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Merck
모든 사진(1)

문서

SAB4700514

Sigma-Aldrich

Monoclonal Anti-TCR beta antibody produced in mouse

clone MEM-262, purified immunoglobulin, buffered aqueous solution

동의어(들):

Anti-TCR β (Vβ5.3-related)

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About This Item

UNSPSC 코드:
12352203
NACRES:
NA.41

생물학적 소스

mouse

결합

unconjugated

항체 형태

purified immunoglobulin

항체 생산 유형

primary antibodies

클론

MEM-262, monoclonal

형태

buffered aqueous solution

종 반응성

human

농도

1 mg/mL

기술

flow cytometry: suitable

동형

IgG2a

NCBI 수납 번호

배송 상태

wet ice

저장 온도

2-8°C

타겟 번역 후 변형

unmodified

유전자 정보

human ... TRB@(6957)

관련 카테고리

일반 설명

The antibody MEM-262 recognizes β chains of the TCR expressed by HPB-ALL cell line [carrying V(beta5.3)] and a small subset of peripheral blood T cells.
TCR β/TCRB (T cell receptor β chain) is located on human chromosome 7q34. This gene has at least 65 rearrangeable Vβ gene segments (27 Vβ families), two Dβ segments (Dβ1 and Dβ2), two clusters of Jβ gene segments (Jβ1.1–Jβ 1.6 and Jβ2.1–Jβ2.7) and two Cβ gene segments.

면역원

Human thymoma cell line HPB-ALL

애플리케이션

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2-8 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

생화학적/생리학적 작용

The complementary determining region 3 (CDR3) of the TCR β/TCRB (T cell receptor β) is essential for the identification of the major histocompatibility complex (MHC)−peptide complex.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

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Storage Class Code

10 - Combustible liquids

Flash Point (°F)

Not applicable

Flash Point (°C)

Not applicable


시험 성적서(COA)

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문서 라이브러리 방문

T-lineage acute lymphoblastic leukemia (T-ALL)
Raimondi S C
Atlas of Genetics and Cytogenetics in Oncology and Haematology (2007)
TCRB gene rearrangements in childhood and adult precursor-B-ALL: frequency, applicability as MRD-PCR target, and stability between diagnosis and relapse
Van der Velden, et al.
Leukemia, 18(12), 1971-1971 (2004)
The T-cell receptor repertoire influences the tumor microenvironment and is associated with survival in aggressive B-cell lymphoma
Keane C, et al.
Clinical Cancer Research, 23(7), 1820-1828 (2017)

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