SAB4700323

Monoclonal Anti-HLA-G , (C-terminal) antibody produced in mouse

clone 5A6G7, purified immunoglobulin, buffered aqueous solution

• UNSPSC 코드: 12352203
• NACRES: NA.41

속성

• 생물학적 소스: mouse
• Quality Level: 100
• 결합: unconjugated
• 항체 형태: purified immunoglobulin
• 항체 생산 유형: primary antibodies
• 클론: 5A6G7, monoclonal
• 형태: buffered aqueous solution
• 종 반응성: human
• 농도: 1 mg/mL
• 기술: flow cytometry: suitable
• 동형: IgG1
• NCBI 수납 번호: NM_002127.5
• UniProt 수납 번호: P17693
• 배송 상태: wet ice
• 저장 온도: 2-8°C
• 타겟 번역 후 변형: unmodified
• 유전자 정보: human ... HLA-G(3135)

설명

일반 설명

Human histocompatibility leukocyte antigen–G (HLA-G) belongs to the non-classical class I HLA family. It is encoded by the gene mapped to human chromosome 6p21. Unlike other members of the human class I gene family, HLA-G is expressed specifically in extraembryonic tissues during gestation.

The antibody 5A6G7 allows to discriminate between soluble HLA-G protein yielded by shedding from membrane-bound HLA-G forms that do not contain the intron 4-encoded epitope and soluble HLA-G5/HLA-G6 produced from intron 4-retaining alternatively spliced mRNAs. HLA-G belongs to the MHC Class I molecules (MHC Class Ib; nonclassical) and it is expressed on the surface of trophoblast cells.

면역원

C-terminal amino acid sequence (22-mer) of soluble HLA-G5 and HLA-G6 proteins coupled to ovalbumin

애플리케이션

The reagent is designed for Flow Cytometry analysis. Suggested working dilution for Flow Cytometry is 2 μg/mL of sample. Indicated dilution is recommended starting point for use of this product. Working concentrations should be determined by the investigator.

생화학적/생리학적 작용

Human histocompatibility leukocyte antigen-G (HLA-G) molecule facilitates the regulation of maternal tolerance to the fetus by interacting with inhibitory receptors on natural killer (NK) cells. The encoded protein is involved in the embryonic development and/or the fetal-maternal immune response. Mutations in the gene increases the risk of susceptibility to a wide range of inflammatory diseases, including asthma.

특징 및 장점

Evaluate our antibodies with complete peace of mind. If the antibody does not perform in your application, we will issue a full credit or replacement antibody. Learn more.

물리적 형태

Solution in phosphate buffered saline, pH 7.4, with 15 mM sodium azide.

면책조항

Unless otherwise stated in our catalog or other company documentation accompanying the product(s), our products are intended for research use only and are not to be used for any other purpose, which includes but is not limited to, unauthorized commercial uses, in vitro diagnostic uses, ex vivo or in vivo therapeutic uses or any type of consumption or application to humans or animals.

안전성 정보

• Storage Class Code: 10 - Combustible liquids
• Flash Point (°F): Not applicable
• Flash Point (°C): Not applicable